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JQ1 (+/-)

Inh 1268524-69-1 (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Produktnummer ABIN7233265
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    Bromodomain inhibitor
    Produktmerkmale
    JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.
    Reinheit
    >98 %
    Chemical Name
    (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
    Formel
    C23H25ClN4O2S
    Löslichkeit
    Soluble in DMSO (up to 9 mg/ml) or in Ethanol (up to 9 mg/ml) with warming.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Vorsichtsmaßnahmen
    GHS – Classification
    Pharmacologically active compound that has not been fully tested
    May be harmful if swallowed, inhaled or absorbed through skin
    Exposure may cause irritation to skin, eyes and upper respiratory tract
    Specific target organ toxicity - unknown
    Lagerung
    RT
  • Hintergrund
    Epigenetics,Proliferation,Bromodomain,Cancer,Posttranslational modification,Chromatin
    Molekulargewicht
    457.00
    CAS-Nummer
    1268524-69-1
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