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- Applikation
- Inhibition (Inh)
- Verwendungszweck
- SIRT1 inhibitor, essential nutrient
- Produktmerkmale
- Essential nutrient (amide form of Vitamin B3) that is incorporated into cofactors NADH/NAD+, important for ATP production and other key metabolic functions. Transiently inhibits SIRT1/SIRT3 through feedback inhibition (IC50 ~ 50 μM), but is quickly converted to NAD+ in cells. Also inhibits certain kinases (e.g. ROCK and CK1), making it a regulator of hPSC pluripotency, survival, and differentiation. Inhibits differentiation and enhances functionality of hematopoietic stem/progenitor cells (HSPCs).
- Reinheit
- >99 %
- Chemical Name
- Pyridine-3-carboxylic acid amide
- Formel
- C6H6N2O
- Löslichkeit
- Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
PanobinostatInh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
HPA (Hexyl-4-pentynoic acid)Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
DaminozideInh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid
Mithramycin AInh 18378-89-7
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Powder
- Lagerung
- RT
-
- Hintergrund
- Nicotinic acid amide, Niacinamide, Vitamin B3, NAM,Epigenetics,DNA damage,Protein deacetylase,Kinase,Stem cells,Cancer,NAD, NADP pathways,Posttranslational modification
- Molekulargewicht
- 122.1
- CAS-Nummer
- 98-92-0
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