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PBIT

Inh 2514-30-9 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one

1 image

Produktnummer ABIN7233273

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

JARID1 inhibitor

Produktmerkmale

The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.

Reinheit

>98 %

Chemical Name

2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one

Formel

C14H11NOS

Löslichkeit

Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
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Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Vorsichtsmaßnahmen

GHS – Classification
Not a hazardous substance or mixture

Lagerung

-20 °C
Hintergrund

Epigenetics,Proliferation,Protein demethylase,Vesicles,Cancer,Posttranslational modification,Chromatin

Molekulargewicht

241.31

CAS-Nummer

2514-30-9