Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PBIT

Inh 2514-30-9 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Produktnummer ABIN7233273
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    JARID1 inhibitor
    Produktmerkmale
    The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.
    Reinheit
    >98 %
    Chemical Name
    2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
    Formel
    C14H11NOS
    Löslichkeit
    Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Vorsichtsmaßnahmen
    GHS – Classification
    Not a hazardous substance or mixture
    Lagerung
    -20 °C
  • Hintergrund
    Epigenetics,Proliferation,Protein demethylase,Vesicles,Cancer,Posttranslational modification,Chromatin
    Molekulargewicht
    241.31
    CAS-Nummer
    2514-30-9
Sie sind hier:
Kundenservice