Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Remodelin

Inh 949912-58-7 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
Produktnummer ABIN7233278
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    Acetyl-transferase NAT10 inhibitor
    Produktmerkmale
    Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.
    Reinheit
    >98 %
    Chemical Name
    4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
    Formel
    C15H14N4S
    Löslichkeit
    Soluble in DMSO (up to 40 mg/ml)
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Lagerung
    -20 °C
  • Hintergrund
    Epigenetics,Nuclear transport,Acetyltransferase,Cytoskeleton,Ageing,Posttranslational modification,Chromatin
    Molekulargewicht
    282.36
    CAS-Nummer
    949912-58-7
Sie sind hier:
Kundenservice