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Remodelin

Name: Remodelin
Brand: antibodies-online
SKU: ABIN7233278
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Inh 949912-58-7 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile

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Produktnummer ABIN7233278

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

Acetyl-transferase NAT10 inhibitor

Produktmerkmale

Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.

Reinheit

>98 %

Chemical Name

4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile

Formel

C15H14N4S

Löslichkeit

Soluble in DMSO (up to 40 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
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Resveratrol
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Panobinostat
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HPA (Hexyl-4-pentynoic acid)
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EX-527
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Daminozide
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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Lagerung

-20 °C
Hintergrund

Epigenetics,Nuclear transport,Acetyltransferase,Cytoskeleton,Ageing,Posttranslational modification,Chromatin

Molekulargewicht

282.36

CAS-Nummer

949912-58-7