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UNC-0379

Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
Produktnummer ABIN7233304
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    SETD8 inhibitor
    Produktmerkmale
    UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases. IC50's = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.
    Reinheit
    >98 %
    Chemical Name
    6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
    Formel
    C23H35N5O2
    Löslichkeit
    Soluble in DMSO (up to 30 mg/ml).
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Lagerung
    -20 °C
  • Hintergrund
    Proliferation,Epigenetics,p53,Protein methyltransferase,Neuroscience,Cancer,Posttranslational modification,Chromatin
    Molekulargewicht
    413.56
    CAS-Nummer
    1620401-82-2
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