SensoLyte® Rh110 Factor Xa Assay Kit
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- Target Alle Factor Xa (FXa) Kits anzeigen
- Factor Xa (FXa) (Activated Coagulation Factor X (FXa))
- Nachweismethode
- Fluorometric
- Applikation
- Fluorescence Resonance Energy Transfer Microscopy (FRET)
- Marke
- SensoLyte®
- Produktmerkmale
- The SensoLyte® Rh110 Factor Xa Assay Kit provides a convenient assay for screening of FXa inhibitors or continuous assay of enzyme activity using a fluorogenic substrate. Upon FXa protease cleavage, this substrate generates the Rh110 (rhodamine 110) fluorophore which has a bright green fluorescence that can be detected at excitation/emission=490 nm/520 nm. The longer-wavelength spectra and higher extinction coefficient of the Rh110 provide greater sensitivity and less interference from other reaction components.
- Top Product
- Discover our top product FXa ELISA Kit
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- Kommentare
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FRET-based Assay Kit
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Handhabung
- Protect Components A and B from light and moisture.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Component D can be stored at room temperature for convenience
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- Target
- Factor Xa (FXa) (Activated Coagulation Factor X (FXa))
- Andere Bezeichnung
- Factor Xa (FXa Produkte)
- Synonyme
- FX Kit, FXA Kit, coagulation factor X Kit, F10 Kit
- Hintergrund
- Factor Xa (FXa) is a serine endopeptidase composed of two disulfide-linked subunits. FXa leads to blood clot formation by converting prothrombin to thrombin through the prothrombinase complex. FXa is generated from zymogen Factor X via the intrinsic and extrinsic pathways and is the rate-limiting step in the propagation of thrombin generation. In the presence of Ca2+ ions, FXa forms prothrombinase with factor Va on the phospholipid membrane of the activated platelets. FXa has emerged as an attractive target for drug discovery for thromboembolic diseases.
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