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CPB2 ELISA Kit

CPB2 Reaktivität: Human AA 1-423 Colorimetric Sandwich ELISA
Produktnummer ABIN5510667
  • Target Alle CPB2 ELISA Kits anzeigen
    CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
    Bindungsspezifität
    AA 1-423
    Reaktivität
    • 9
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Nachweismethode
    Colorimetric
    Methodentyp
    Sandwich ELISA
    Applikation
    ELISA
    Verwendungszweck
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human TAFI/CPB2
    Marke
    PicoKine™
    Analytische Methode
    Quantitative
    Spezifität
    Expression system for standard: NSO
    Immunogen sequence: M1-V423
    Kreuzreaktivität (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Produktmerkmale

    Tissue Specificity: Plasma, synthesized in the liver.

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  • Plattentyp
    Pre-coated
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Haltbarkeit
    12 months
  • Target Alle CPB2 ELISA Kits anzeigen
    CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
    Andere Bezeichnung
    CPB2 (CPB2 Produkte)
    Hintergrund

    Protein Function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. .

    Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

    Synonyms: Carboxypeptidase B2,3.4.17.20 ,Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI,CPB2,

    Full Gene Name: Carboxypeptidase B2

    Cellular Localisation: Secreted.
    UniProt
    Q96IY4
    Pathways
    Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
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