SIGLEC5 ELISA Kit

Produktnummer ABIN5510738

Produktdetails SIGLEC5 ELISA Kit

Target: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Bindungsspezifität: AA 17-441

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Siglec5

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO, Immunogen sequence: E17-L441

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu SIGLEC5

Target: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Andere Bezeichnung: SIGLEC5 (SIGLEC5 Produkte)

Synonyme: CD170 ELISA Kit, CD33L2 ELISA Kit, OB-BP2 ELISA Kit, OBBP2 ELISA Kit, SIGLEC-5 ELISA Kit, sialic acid binding Ig like lectin 5 ELISA Kit, sialic acid-binding Ig-like lectin 5 ELISA Kit, sialic acid binding Ig-like lectin 5 ELISA Kit, SIGLEC5 ELISA Kit, LOC100597560 ELISA Kit, Siglec5 ELISA Kit

Hintergrund:

Protein Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Background: Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Synonyms: Sialic acid-binding Ig-like lectin 5,Siglec-5,CD33 antigen-like 2,Obesity-binding protein 2,OB-BP2,OB-binding protein 2,CD170,SIGLEC5,CD33L2, OBBP2,

Full Gene Name: Sialic acid-binding Ig-like lectin 5

Cellular Localisation: Membrane, Single-pass type I membrane protein.

UniProt: O15389