Annexin V ELISA Kit

Produktnummer ABIN930753

Produktdetails Annexin V ELISA Kit

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Reaktivität: Chemical

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Analytische Methode: Quantitative

Produktmerkmale: ELISA kit for the detection of Annexin V in the research laboratory
Alternative Names: Annexin V ELISA kit

Anwendungsinformationen

Applikationshinweise: Optimal conditions to be determined by end-user

Plattentyp: Pre-coated

Testdurchführung:

The Antiannexin V IgG/IgM is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG or IgM class autoantibodies directed against annexin V. The microplate is coated with highly purified human recombinant annexin V. The microplate can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8 °C.

Details zu Annexin V

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Andere Bezeichnung: Annexin V (ANXA5 Produkte)

Substanzklasse: Chemical

Hintergrund: Annexin V, also known as placental anticoagulant protein I (PAP I), not only belongs to a family of proteins that bind to phospholipids in a calcium dependent manner, but is also a potent vascular anticoagulant protein. Annexin V is necessary to maintain placental integrity and may have a thrombo-regulatory effect at the materno-fetal interface, as shown in a murine model. It has been suggested, that interference of anti-annexin V antibodies with the annexin V shield on the placental villi leads to the exposure of anionic procoagulant phospholipids. Anionic procoagulant phospholipids are known to enhance blood coagulation processes in the placental vasculature, and may be an important contributory factor of thrombosis and recurrent loss of pregnancy in the APS. Anti-annexin V antibodies are not only highly specific for APS, but also elevated levels of antibodies are detected in patients with systemic lupus diseases (SLE). It has been suggested that anti-annexin V autoantibodies may influence in the clinical course of rheumatoid arthritis. A significantly high frequency of arterial or venous thrombosis is found in patients with anti-annexin V antibodies. And are a significant risk factor for recurrent miscarriages in SLE patients.
Synonyms: Annexin V ELISA kit.

Pathways: Apoptose