KLRK1 Produkte
(Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
Kategorien
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010].
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Ausgewählte KLRK1 Kategorien
KLRK1 Antikörper
High quality antibodies with extensive validation data.
KLRK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
KLRK1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene KLRK1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, FACS, ELISA
Validierungen
- (6)
Kat. Nr.
ABIN7193627
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
FACS
Validierungen
- (7)
- (4)
Kat. Nr.
ABIN1027688
Menge
100 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, FACS, ELISA, IHC (fro), IF (cc), IF (p), IHC (p)
Validierungen
- (3)
- (4)
Kat. Nr.
ABIN730078
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene KLRK1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730443
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN4882179
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6385461
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene KLRK1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (6)
Kat. Nr.
ABIN7275337
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7275342
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cynomolgus
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7275334
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren KLRK1 Produkten
: "Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis." in: RNA biology, Vol. 16, Issue 11, pp. 1592-1603, (2019) (PubMed).: "Quantitative and functional analysis of CD69(+) T regulatory lymphocytes in patients with periodontal disease." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, (2016) (PubMed).
: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." in: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).
: "NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma." in: Oncotarget, Vol. 7, Issue 42, pp. 68513-68526, (2016) (PubMed).
: "A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease." in: Infection, Vol. 43, Issue 3, pp. 353-9, (2015) (PubMed).
: "Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain." in: BMC cancer, Vol. 15, pp. 1011, (2015) (PubMed).
: "Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human ..." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004671, (2015) (PubMed).
: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).
: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).
: "NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134568, (2015) (PubMed).
Synonyme und alternative Namen zu KLRK1
killer cell lectin like receptor K1 (KLRK1), killer cell lectin-like receptor subfamily K, member 1 (KLRK1), killer cell lectin-like receptor subfamily K, member 1 (Klrk1), killer cell lectin like receptor K1 (Klrk1), NKG2D protein (NKG2D), CD314, D6H12S2489E, D12S2489E, KLR, KLRK1, NKG2-D, NKG2D, Nkg2d, Nkrp2Bezeichner auf Proteinebene für KLRK1
- killer cell lectin-like receptor subfamily K, member 1
- NKG2-D type II integral membrane protein-like
- NK cell receptor D
- NKG2-D type II integral membrane protein
- NKG2-D-activating NK receptor
- natural killer cell group 2D
- NK lectin-like receptor
- NKLLR
- NKR-P2, ortholog of human NKG2D
- killer cell lectin-like receptor subfamily K member 1
- NKG2-D activating NK receptor
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