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LARGE Produkte

(Like-Glycosyltransferase (LARGE))
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].

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Ausgewählte LARGE Kategorien

LARGE Antikörper

High quality antibodies with extensive validation data.

LARGE ELISA Kits

Reliable ELISA kits for a wide range of species.

LARGE Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene LARGE Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IP, IHC, ICC
Validierungen
  • (2)
Kat. Nr. ABIN7443668
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB
Validierungen
  • (1)
Kat. Nr. ABIN6243442
Menge 50 μL
Datenblatt Datenblatt
Reaktivität Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Applikation WB
Validierungen
  • (1)
Kat. Nr. ABIN6743423
Menge 100 μL
Datenblatt Datenblatt

Empfohlene LARGE ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1135279
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1135280
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Chicken
Analytical Method
Validierungen
Kat. Nr. ABIN1135278
Menge 96 tests
Datenblatt Datenblatt

Empfohlene LARGE Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1309153
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7417102
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Guinea Pig
Source Yeast
Validierungen
Kat. Nr. ABIN1660890
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren LARGE Produkten

Saito, Kanagawa, Ikeda, Hagiwara, Masaki, Ohkuma, Katanosaka, Shimizu, Sonoo, Toda, Matsumura: "Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice." in: Human molecular genetics, Vol. 23, Issue 17, pp. 4543-58, (2014) (PubMed).

Reissner, Stahn, Breuer, Klose, Pohlentz, Mormann, Missler: "Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27585-603, (2014) (PubMed).

de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: "Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11279-84, (2009) (PubMed).

Synonyme und alternative Namen zu LARGE

LARGE xylosyl- and glucuronyltransferase 1 L homeolog (large1.L), LARGE xylosyl- and glucuronyltransferase 1 (LARGE1), LARGE xylosyl- and glucuronyltransferase 1 (Large1), LARGE xylosyl- and glucuronyltransferase 1 (large1), glycosyltransferase-like protein LARGE1 (LOC100118066), like-glycosyltransferase (LARGE), like-glycosyltransferase (Large), BPFD36, DKFZp459G0120, enr, fg, froggy, Gyltl1a, gyltl1b, gyltl1b-b, Mbp-1, Mbp1, mdc1d, MDC1D, MDDGA6, MDDGB6, mKIAA0609, myd, NV15834

Bezeichner auf Proteinebene für LARGE

  • glycosyltransferase-like 1B
  • glycosyltransferase-like 1B-B
  • glycosyltransferase-like protein LARGE2-B
  • acetylglucosaminyltransferase-like 1A
  • acetylglucosaminyltransferase-like protein
  • glycosyltransferase-like protein LARGE1
  • like-acetylglucosaminyltransferase
  • myodystrophy
  • glycosyltransferase-like 1A
  • like-glycosyltransferase
  • glycosyltransferase-like protein LARGE1-like
  • eosinophil granule major basic protein 1
  • prepro major basic protein 1
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