LATS1 Produkte
(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
Kategorien
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
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Ausgewählte LATS1 Kategorien
LATS1 Antikörper
High quality antibodies with extensive validation data.
Empfohlene LATS1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IP, IF
Validierungen
- (5)
Kat. Nr.
ABIN7169059
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN391033
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN522568
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene LATS1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968208
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LATS1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123723
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309191
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5508984
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LATS1 Produkten
: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." in: Cells, Vol. 8, Issue 12, (2020) (PubMed).: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." in: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).
: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." in: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).
: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." in: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).
: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).
: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).
Synonyme und alternative Namen zu LATS1
large tumor suppressor kinase 1 (LATS1), large tumor suppressor (Lats1), large tumor suppressor kinase 1 (lats1), large tumor suppressor kinase 1 (Lats1), large tumor suppressor kinase 1 S homeolog (lats1.S), AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, warts, wts, wu:fc19a11, zgc:123219Bezeichner auf Proteinebene für LATS1
- LATS (large tumor suppressor, Drosophila) homolog 1
- LATS, large tumor suppressor, homolog 1
- WARTS protein kinase
- h-warts
- large tumor suppressor homolog 1
- serine/threonine-protein kinase LATS1
- large tumor supressor, homolog 1
- large tumor suppressor 1
- large tumor suppressor
- LATS homolog 1
- LATS, large tumor suppressor, homolog 1 (Drosophila)
- serine/threonine-protein kinase LATS1-like
- large tumor suppressor kinase 1 S homeolog
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