LCK Produkte
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Kategorien
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].
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Ausgewählte LCK Kategorien
LCK Antikörper
High quality antibodies with extensive validation data.
LCK ELISA Kits
Reliable ELISA kits for a wide range of species.
LCK Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LCK Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IP, RNAi
Validierungen
- (6)
Kat. Nr.
ABIN561649
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (6)
Kat. Nr.
ABIN3023130
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, FACS, IP, ICC
Validierungen
- (7)
- (4)
Kat. Nr.
ABIN94422
Menge
0.1 mg
Datenblatt
Datenblatt
Empfohlene LCK ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN4886174
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380629
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380225
Menge
2 x 96 tests
Datenblatt
Datenblatt
Empfohlene LCK Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309226
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309224
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5508986
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LCK Produkten
: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." in: eLife, Vol. 10, (2021) (PubMed).: "Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148." in: The Journal of biological chemistry, Vol. 286, Issue 25, pp. 22101-12, (2011) (PubMed).
: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
: "Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria." in: American journal of physiology. Cell physiology, Vol. 298, Issue 3, pp. C740-8, (2010) (PubMed).
: "The effects of membrane compartmentalization of Csk on TCR signaling." in: Biochimica et biophysica acta, (2010) (PubMed).
: "Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease." in: Infection and immunity, Vol. 78, Issue 11, pp. 4589-92, (2010) (PubMed).
: "Protein tyrosine kinase p56lck-deficiency confers hypersusceptibility to rho-fluorophenylalanine (pFPhe)-induced apoptosis by augmenting mitochondrial apoptotic pathway in human Jurkat T cells." in: Biochemical and biophysical research communications, Vol. 377, Issue 1, pp. 280-5, (2008) (PubMed).
: "Suppression of proximal T cell receptor signaling and lytic function in CD8+ tumor-infiltrating T cells." in: Cancer research, Vol. 67, Issue 23, pp. 11447-54, (2007) (PubMed).
: "Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2262-71, (2007) (PubMed).
: "A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." in: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).
Synonyme und alternative Namen zu LCK
LCK proto-oncogene, Src family tyrosine kinase (lck), LCK proto-oncogene, Src family tyrosine kinase (LCK), lymphocyte protein tyrosine kinase (Lck), LCK proto-oncogene, Src family tyrosine kinase (Lck), Hck-3, LCK, Lck1, Lcktkr, Lsk, LSK, Lskt, p56Bezeichner auf Proteinebene für LCK
- lymphocyte protein tyrosine kinase
- lymphocyte-specific protein tyrosine kinase
- tyrosine-protein kinase Lck-like
- leukocyte C-terminal Src kinase
- lymphocyte cell-specific protein-tyrosine kinase
- proto-oncogene tyrosine-protein kinase LCK
- T-lymphocyte specific protein tyrosine kinase p56lck
- p56(LSTRA) protein-tyrosine kinase
- t cell-specific protein-tyrosine kinase
- tyrosine-protein kinase Lck
- tyrosine protein kinase
- tyrosine-protein kinase LCK
- p56-LCK
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