LCP2 Produkte
(Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
Kategorien
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008].
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Ausgewählte LCP2 Kategorien
LCP2 Antikörper
High quality antibodies with extensive validation data.
LCP2 ELISA Kits
Reliable ELISA kits for a wide range of species.
LCP2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LCP2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, ICC
Validierungen
- (4)
Kat. Nr.
ABIN1859636
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN94501
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (2)
Kat. Nr.
ABIN3023382
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene LCP2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN5691942
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1141096
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1141097
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LCP2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309248
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Baculovirus infected Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN7281315
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2115473
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LCP2 Produkten
: "Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ..." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 17963-74, (2012) (PubMed).: "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 6, pp. 2493-7, (2012) (PubMed).
: "T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component." in: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7535-47, (2011) (PubMed).
: "Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation." in: The Journal of cell biology, Vol. 195, Issue 5, pp. 839-53, (2011) (PubMed).
: "Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2937-46, (2007) (PubMed).
: "SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 16, pp. 6638-43, (2007) (PubMed).
: "A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76." in: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 681-91, (2007) (PubMed).
: "SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond." in: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 67-78, (2006) (PubMed).
: "The SLP-76 family of adapter proteins." in: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).
: "Adaptor proteins in lymphocyte activation." in: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).
Synonyme und alternative Namen zu LCP2
lymphocyte cytosolic protein 2 (Lcp2), lymphocyte cytosolic protein 2 (LCP2), AI323664, BB161688, SLP-76, SLP76, Slp76, twmBezeichner auf Proteinebene für LCP2
- SH2 domain-containing leukocyte protein of 76 kDa
- SLP-76 tyrosine phosphoprotein
- lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
- 76 kDa tyrosine phosphoprotein
- SH2 domain-containing leukocyte protein of 76kD
- lymphocyte cytosolic protein 2
- tyrosine phosphoprotein slp-76
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