LIG4 Produkte
(Ligase IV, DNA, ATP-Dependent (LIG4))
Kategorien
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
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Ausgewählte LIG4 Kategorien
LIG4 Antikörper
High quality antibodies with extensive validation data.
LIG4 ELISA Kits
Reliable ELISA kits for a wide range of species.
LIG4 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LIG4 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (4)
Kat. Nr.
ABIN6262967
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (2)
- (3)
Kat. Nr.
ABIN3022475
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN2778272
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene LIG4 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6216177
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LIG4 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309405
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092165
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3136262
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LIG4 Produkten
: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." in: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining." in: Nature cell biology, Vol. 19, Issue 1, pp. 68-75, (2017) (PubMed).
: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." in: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).
: "An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e55493, (2013) (PubMed).
: "The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2." in: Journal of virology, Vol. 86, Issue 5, pp. 2400-15, (2012) (PubMed).
: "The HTLV-1 Tax oncoprotein represses Ku80 gene expression." in: Virology, Vol. 416, Issue 1-2, pp. 1-8, (2011) (PubMed).
Synonyme und alternative Namen zu LIG4
ligase IV, DNA, ATP-dependent (lig4), DNA ligase 4 (LIG4), DNA ligase 4 (LOC100212302), DNA ligase 4 (CpipJ_CPIJ005161), DNA ligase 4 (PTRG_09982), DNA ligase 4 (MCYG_05151), DNA ligase 4 (LOC657210), ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4), DNA ligase IV (ATLIG4), ligase IV, DNA, ATP-dependent L homeolog (lig4.L), ligase IV, DNA, ATP-dependent (Lig4), DNA ligase 4 (Lig4), 5830471N16Rik, DNA LIGASE IV, DNL4, lig4, LIG4, lig4-A, tiny, zgc:165595Bezeichner auf Proteinebene für LIG4
- DNA ligase 4
- ligase IV, DNA, ATP-dependent
- DNA ligase IV
- DNA ligase (ATP) 4
- GLEAN_12219
- ligase4-like protein
- DNA ligase 4-like
- dsDNA break repair ligase
- polydeoxyribonucleotide synthase [ATP] 4
- DNA joinase
- DNA repair enzyme
- polynucleotide ligase
- sealase
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