LRP2 Produkte
(Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
Kategorien
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].
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Ausgewählte LRP2 Kategorien
LRP2 Antikörper
High quality antibodies with extensive validation data.
LRP2 ELISA Kits
Reliable ELISA kits for a wide range of species.
LRP2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LRP2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
FACS, IF (cc), IF (p)
Validierungen
- (1)
Kat. Nr.
ABIN750991
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validierungen
- (2)
- (4)
Kat. Nr.
ABIN750988
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7158571
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene LRP2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968352
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968350
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6999575
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LRP2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7397174
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Yeast
Validierungen
- (1)
Kat. Nr.
ABIN5713618
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LRP2 Produkten
: "Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension." in: Journal of the American Heart Association, Vol. 8, Issue 8, pp. e012395, (2019) (PubMed).: "IL-6/Smad2 signaling mediates acute kidney injury and regeneration in a murine model of neonatal hyperoxia." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 5887-5902, (2019) (PubMed).
: "Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule." in: International journal of molecular sciences, Vol. 20, Issue 10, (2019) (PubMed).
: "A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells." in: Stem cell reports, Vol. 11, Issue 2, pp. 470-484, (2018) (PubMed).
: "Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis." in: Journal of the American Society of Nephrology : JASN, Vol. 29, Issue 11, pp. 2696-2712, (2018) (PubMed).
: "Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism." in: Cellular and molecular life sciences : CMLS, Vol. 75, Issue 21, pp. 4021-4040, (2018) (PubMed).
: "Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies." in: Placenta, Vol. 42, pp. 9-16, (2016) (PubMed).
: "Role of serotonin in the regulation of renal proximal tubular epithelial cells." in: Renal failure, Vol. 38, Issue 7, pp. 1141-50, (2016) (PubMed).
: "Rho GAP myosin IXa is a regulator of kidney tubule function." in: American journal of physiology. Renal physiology, Vol. 309, Issue 6, pp. F501-13, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." in: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
Synonyme und alternative Namen zu LRP2
LDL receptor related protein 2 (LRP2), low density lipoprotein receptor-related protein 2a (lrp2a), low density lipoprotein receptor-related protein 2 (LRP2), low-density lipoprotein receptor-related protein 2 (LRP2.3), LDL receptor related protein 2 L homeolog (lrp2.L), low-density lipoprotein receptor-related protein 2 (LOC100183506), LDL receptor related protein 2 (lrp2), low density lipoprotein receptor-related protein 2 (Lrp2), LDL receptor related protein 2 (Lrp2), AI315343, AW536255, D230004K18Rik, dbs, DBS, gp330, GP330, Gp330, im:680590, lrp2, megalin, MegalinBezeichner auf Proteinebene für LRP2
- low density lipoprotein-related protein 2
- gp330b
- low-density lipoprotein receptor-related protein 2
- megalin
- low density lipoprotein receptor-related protein 2
- low-density lipoprotein receptor-related protein 2-like
- Heymann nephritis antigen homolog
- LRP-2
- calcium sensor protein
- glycoprotein 330
- gp330
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