Lysine (K)-Specific Methyltransferase 2A Antikörper
(Lysine (K)-Specific Methyltransferase 2A (KMT2A))
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
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Ausgewählte Lysine (K)-Specific Methyltransferase 2A Kategorien
Lysine (K)-Specific Methyltransferase 2A Antikörper
High quality antibodies with extensive validation data.
Empfohlene Lysine (K)-Specific Methyltransferase 2A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC, FACS, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN328575
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC, FACS, IHC (p)
Validierungen
Kat. Nr.
ABIN1840980
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Guinea Pig, Horse, Human, Mouse, Rat
Applikation
WB, IP, ChIP, PLA
Validierungen
Kat. Nr.
ABIN1908616
Menge
100 μL
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Lysine (K)-Specific Methyltransferase 2A Produkten
: "HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice." in: Cancer cell, Vol. 36, Issue 6, pp. 645-659.e8, (2019) (PubMed).: "Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development." in: Cell reports, Vol. 16, Issue 4, pp. 1039-54, (2016) (PubMed).
: "Epigenetic regulation of IL-12-dependent T cell proliferation." in: Journal of leukocyte biology, Vol. 98, Issue 4, pp. 601-13, (2015) (PubMed).
: "Reduction of Hox gene expression by histone H1 depletion." in: PLoS ONE, Vol. 7, Issue 6, pp. e38829, (2012) (PubMed).
: "Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia." in: PLoS genetics, Vol. 8, Issue 6, pp. e1002781, (2012) (PubMed).
: "Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 3, pp. 1182-92, (2012) (PubMed).
: "Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation." in: PLoS genetics, Vol. 8, Issue 7, pp. e1002840, (2012) (PubMed).
: "MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome." in: Blood, Vol. 117, Issue 25, pp. 6895-905, (2011) (PubMed).
: "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}." in: The Journal of biological chemistry, Vol. 286, Issue 2, pp. 1354-63, (2011) (PubMed).
: "Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies." in: Molecular and cellular biology, Vol. 30, Issue 8, pp. 2046-56, (2010) (PubMed).
Synonyme und alternative Namen zu Lysine (K)-Specific Methyltransferase 2A
lysine (K)-specific methyltransferase 2A (Kmt2a), 6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, mKIAA4050, Mll, Mll1Bezeichner auf Proteinebene für Lysine (K)-Specific Methyltransferase 2A
- histone-lysine N-methyltransferase 2A
- histone-lysine N-methyltransferase MLL
- lysine N-methyltransferase 2A
- myeloid/lymphoid or mixed-lineage leukemia 1
- myeloid/lymphoid or mixed-lineage leukemia protein 1
- trithorax Drosophila
- zinc finger protein HRX
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