MANF Produkte
(Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
Kategorien
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010].
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Ausgewählte MANF Kategorien
MANF Antikörper
High quality antibodies with extensive validation data.
MANF ELISA Kits
Reliable ELISA kits for a wide range of species.
MANF Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MANF Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, IP
Validierungen
- (7)
Kat. Nr.
ABIN6143461
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (3)
Kat. Nr.
ABIN7426499
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IF, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN6990751
Menge
0.1 mg
Datenblatt
Datenblatt
Empfohlene MANF ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN6957758
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6957759
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6957760
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MANF Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (2)
Kat. Nr.
ABIN5509524
Menge
40 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123914
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1345666
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MANF Produkten
: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).: "Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice." in: Neurobiology of disease, Vol. 134, pp. 104696, (2020) (PubMed).
: "MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System." in: eNeuro, Vol. 7, Issue 1, (2020) (PubMed).
: "MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex." in: eNeuro, Vol. 4, Issue 5, (2018) (PubMed).
: "Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance." in: Endocrine journal, Vol. 64, Issue 4, pp. 403-410, (2017) (PubMed).
: "Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling." in: The Journal of steroid biochemistry and molecular biology, Vol. 171, pp. 94-109, (2017) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing." in: PLoS ONE, Vol. 7, Issue 6, pp. e39359, (2012) (PubMed).
: "MANF regulates dopaminergic neuron development in larval zebrafish." in: Developmental biology, Vol. 370, Issue 2, pp. 237-49, (2012) (PubMed).
: "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." in: Nature, Vol. 448, Issue 7149, pp. 73-7, (2007) (PubMed).
Synonyme und alternative Namen zu MANF
mesencephalic astrocyte derived neurotrophic factor (MANF), mesencephalic astrocyte-derived neurotrophic factor (Manf), RNA binding motif protein 15B (RBM15B), Mesencephalic astrocyte-derived neurotrophic factor (Manf), mesencephalic astrocyte-derived neurotrophic factor (manf), mesencephalic astrocyte derived neurotrophic factor (Manf), mesencephalic astrocyte-derived neurotrophic factor S homeolog (manf.S), 3230402M22Rik, AA407711, AA408789, AA673178, anon-EST:ParkEST188, ARMET, Armet, armet, ARP, arp, ARP-like, CG7013, D18Mgi17, D17914, Dmel\\CG7013, DmMANF, im:6909481, MANF, manf, RBM15B, zgc:153327Bezeichner auf Proteinebene für MANF
- arginine-rich, mutated in early stage tumors
- arginine-rich protein
- mesencephalic astrocyte-derived neurotrophic factor
- RNA binding motif protein 15B
- chromosome 3p21.1 gene sequence
- CG7013-PA
- Manf-PA
- ARP-like
- LOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor
- mesencephalic astrocyte-derived neurotrophic factor S homeolog
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