MAP3K12 Produkte
(Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12))
Kategorien
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010].
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Ausgewählte MAP3K12 Kategorien
MAP3K12 Antikörper
High quality antibodies with extensive validation data.
MAP3K12 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MAP3K12 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC (p)
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN391319
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7235601
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC
Validierungen
- (3)
Kat. Nr.
ABIN3031847
Menge
0.4 mL
Datenblatt
Datenblatt
Empfohlene MAP3K12 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7414819
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3083503
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3122717
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MAP3K12 Produkten
: "Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons." in: Neuron, Vol. 94, Issue 6, pp. 1142-1154.e6, (2017) (PubMed).: "MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 36, Issue 2, pp. 712-26, (2015) (PubMed).
: "ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 32, pp. 10729-42, (2014) (PubMed).
: "The DLK gene is a transcriptional target of PPAR?." in: The Biochemical journal, Vol. 438, Issue 1, pp. 93-101, (2011) (PubMed).
: "The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12732-41, (2005) (PubMed).
: "Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo." in: Gene expression patterns : GEP, Vol. 5, Issue 4, pp. 517-23, (2005) (PubMed).
: "SP3 acts as a positive regulator on the core promoter of human ZPK gene." in: Biochemical and biophysical research communications, Vol. 313, Issue 3, pp. 612-8, (2003) (PubMed).
: "MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo." in: Development (Cambridge, England), Vol. 129, Issue 19, pp. 4483-95, (2002) (PubMed).
: "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21247-54, (2000) (PubMed).
: "Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 10, pp. 1287-96, (1999) (PubMed).
Synonyme und alternative Namen zu MAP3K12
mitogen-activated protein kinase kinase kinase 12 (MAP3K12), mitogen activated protein kinase kinase kinase 12 (Map3k12), mitogen-activated protein kinase kinase kinase 12 (Map3k12), mitogen-activated protein kinase kinase kinase 12 (map3k12), mitogen-activated protein kinase kinase kinase 12 S homeolog (map3k12.S), mitogen-activated protein kinase kinase kinase 12 L homeolog (map3k12.L), DKFZp459K2433, DLK, dlk, map3k12, map3k12-a, map3k12-b, map3k12a, map3k12b, MEKK12, mekk12, MGC151798, MUK, muk, PK, zgc:77370, ZPK, Zpk, zpk, ZPKP1, zpkp1Bezeichner auf Proteinebene für MAP3K12
- MAPK-upstream kinase
- dual leucine zipper bearing kinase
- dual leucine zipper kinase DLK
- leucine zipper protein kinase
- mixed lineage kinase
- protein kinase MUK
- Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
- Zipper (leucine) protein kinase
- dual leucine zipper kinase
- leucine-zipper protein kinase
- mitogen-activated protein kinase kinase kinase 12
- mitogen activated protein kinase kinase kinase 12
- zipper (leucine) protein kinase
- mitogen activated protein kinase kinase kinase 12 type A
- mitogen activated protein kinase kinase kinase 12 type B
- mitogen-activated protein kinase kinase kinase 12 L homeolog
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