MAP3K3 Produkte
(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
Kategorien
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Ausgewählte MAP3K3 Kategorien
MAP3K3 Antikörper
High quality antibodies with extensive validation data.
MAP3K3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MAP3K3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN7268652
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC
Validierungen
- (3)
Kat. Nr.
ABIN7258882
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN3044008
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene MAP3K3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310214
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310216
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5509009
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MAP3K3 Produkten
: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).
: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." in: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).
: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." in: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).
: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).
Synonyme und alternative Namen zu MAP3K3
mitogen activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (MAP3K3), mitogen-activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (map3k3), AW548911, MAPKKK3, MEKK3, Mekk3, mKIAA4031Bezeichner auf Proteinebene für MAP3K3
- mitogen-activated protein kinase kinase kinase 3
- MAP/ERK kinase kinase 3
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
- mitogen activated protein kinase kinase kinase 3
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