MAP3K4 Produkte
(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
Kategorien
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Ausgewählte MAP3K4 Kategorien
MAP3K4 Antikörper
High quality antibodies with extensive validation data.
MAP3K4 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MAP3K4 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN561801
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC, WB
Validierungen
- (4)
Kat. Nr.
ABIN7268654
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, PLA
Validierungen
- (3)
Kat. Nr.
ABIN561800
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene MAP3K4 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6219424
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MAP3K4 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310218
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2750508
Menge
5 applications
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MAP3K4 Produkten
: "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39366-73, (2004) (PubMed).: "Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37451-8, (2003) (PubMed).
: "Oligomerization of human Gadd45a protein." in: The Journal of biological chemistry, Vol. 276, Issue 42, pp. 39330-9, (2001) (PubMed).
Synonyme und alternative Namen zu MAP3K4
mitogen activated protein kinase kinase kinase 4 (Map3k4), mitogen-activated protein kinase kinase kinase 4 (MAP3K4), mitogen-activated protein kinase kinase kinase 4 (Map3k4), D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK4, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, TasBezeichner auf Proteinebene für MAP3K4
- mitogen-activated protein kinase kinase kinase 4
- MAP three kinase 1
- MAP/ERK kinase kinase 4
- MAPK/ERK kinase kinase 4
- MEK kinase 4
- MEKK 4
- SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
- dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)
- predicted protein of HQ0412
- T-associated sex reversal
- mitogen activated protein kinase kinase kinase 4
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