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MAP3K8 Produkte

(Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].

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Ausgewählte MAP3K8 Kategorien

MAP3K8 Antikörper

High quality antibodies with extensive validation data.

MAP3K8 ELISA Kits

Reliable ELISA kits for a wide range of species.

MAP3K8 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene MAP3K8 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IHC (p)
Validierungen
  • (5)
Kat. Nr. ABIN701275
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC, IF
Validierungen
  • (4)
Kat. Nr. ABIN7160057
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC (p), IF, ICC
Validierungen
  • (4)
Kat. Nr. ABIN2855464
Menge 100 μL
Datenblatt Datenblatt

Empfohlene MAP3K8 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380113
Menge 2 x 96 tests
Datenblatt Datenblatt

Empfohlene MAP3K8 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1310239
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1310237
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Baculovirus infected Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN7317083
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren MAP3K8 Produkten

Jeong, Bhatia, Toth, Oh, Inn, Liao, Roy-Burman, Melamed, Coetzee, Jung: "TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth." in: PLoS ONE, Vol. 6, Issue 1, pp. e16205, (2011) (PubMed).

Jager, Grémeaux, Gonzalez, Bonnafous, Debard, Laville, Vidal, Tran, Gual, Le Marchand-Brustel, Cormont, Tanti: "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis." in: Diabetes, Vol. 59, Issue 1, pp. 61-70, (2009) (PubMed).

Mielke, Elkins, Wei, Starr, Tsichlis, OShea, Watford: "Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7984-93, (2009) (PubMed).

Lee, Lee, Bode, Lee, Dong: "Tpl2 is a key mediator of arsenite-induced signal transduction." in: Cancer research, Vol. 69, Issue 20, pp. 8043-9, (2009) (PubMed).

ONeill: "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction." in: Immunity, Vol. 29, Issue 1, pp. 12-20, (2008) (PubMed).

Sánchez-Góngora, Lisbona, de Gregorio, Ballester, Calvo, Pérez-Jurado, Alemany: "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31379-86, (2000) (PubMed).

Synonyme und alternative Namen zu MAP3K8

mitogen-activated protein kinase kinase kinase 8 (MAP3K8), mitogen-activated protein kinase kinase kinase 8 (map3k8), mitogen-activated protein kinase kinase kinase 8 (Map3k8), c-COT, COT, Cot, Cot/Tpl2, D17TPL2, EST, Est, ESTF, Estf, MAP3K8, MEKK8, Tpl-2, TPL2, Tpl2

Bezeichner auf Proteinebene für MAP3K8

  • mitogen-activated protein kinase kinase kinase 8
  • Ewing sarcoma transformant
  • cot (cancer Osaka thyroid) oncogene
  • proto-oncogene c-Cot
  • proto-oncogene serine/threoine protein kinase
  • tumor progression locus 2
  • COT proto-oncogene serine/threonine-protein kinase
  • cancer Osaka thyroid oncogene
  • cancer Osaka thyroid, oncogene
  • mitogen activated protein kinase kinase kinase 8
  • serine/threonine-protein kinase cot
  • serine/threonine kinase (Tpl-2)
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