MBD2 Produkte
(Methyl-CpG Binding Domain Protein 2 (MBD2))
Kategorien
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
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Ausgewählte MBD2 Kategorien
MBD2 Antikörper
High quality antibodies with extensive validation data.
MBD2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MBD2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (2)
- (4)
Kat. Nr.
ABIN334432
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (3)
- (2)
Kat. Nr.
ABIN1881531
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN2779675
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene MBD2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7417450
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3083393
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3120369
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MBD2 Produkten
: "lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures." in: Genes & development, Vol. 32, Issue 11-12, pp. 836-848, (2018) (PubMed).: "Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor." in: Molecular cell, Vol. 56, Issue 6, pp. 738-48, (2014) (PubMed).
: "A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein." in: PLoS ONE, Vol. 6, Issue 10, pp. e25884, (2012) (PubMed).
: "CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex." in: Molecular bioSystems, Vol. 6, Issue 9, pp. 1700-6, (2010) (PubMed).
: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).
: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, (2010) (PubMed).
: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, (2009) (PubMed).
: "Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive ..." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 1, pp. 142-53, (2009) (PubMed).
: "Control of the DNA methylation system component MBD2 by protein arginine methylation." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7224-35, (2006) (PubMed).
: "MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties." in: Molecular and cellular biology, Vol. 26, Issue 3, pp. 843-51, (2006) (PubMed).
Synonyme und alternative Namen zu MBD2
methyl-CpG binding domain protein 2 (MBD2), methyl-CpG binding domain protein 2 (Mbd2), methyl-CpG binding domain protein 2 (mbd2), methyl-CpG binding domain protein 2 S homeolog (mbd2.S), DMTase, MBD2, MBD2a, NY-CO-41, wu:fa97f06, zgc:111862Bezeichner auf Proteinebene für MBD2
- methyl-CpG binding domain protein 2
- demethylase
- methyl-CpG-binding domain protein 2
- methyl-CpG-binding protein MBD2
- methyl-CpG binding protein MBD2
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