MCFD2 Produkte
(Multiple Coagulation Factor Deficiency 2 (MCFD2))
Kategorien
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1\; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D)\; a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010].
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Ausgewählte MCFD2 Kategorien
MCFD2 Antikörper
High quality antibodies with extensive validation data.
MCFD2 ELISA Kits
Reliable ELISA kits for a wide range of species.
MCFD2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MCFD2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), RNAi
Validierungen
- (6)
Kat. Nr.
ABIN566639
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (3)
Kat. Nr.
ABIN4911821
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (2)
Kat. Nr.
ABIN1327026
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene MCFD2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968701
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968702
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1143338
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MCFD2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN666930
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310538
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2130495
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MCFD2 Produkten
: "Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex." in: Traffic (Copenhagen, Denmark), Vol. 7, Issue 11, pp. 1473-81, (2006) (PubMed).: "Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency of factor V and VIII." in: American journal of hematology, Vol. 79, Issue 4, pp. 262-6, (2005) (PubMed).
: "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway." in: The Journal of biological chemistry, Vol. 280, Issue 27, pp. 25881-6, (2005) (PubMed).
Synonyme und alternative Namen zu MCFD2
multiple coagulation factor deficiency 2 (MCFD2), multiple coagulation factor deficiency 2 (mcfd2), multiple coagulation factor deficiency 2 L homeolog (mcfd2.L), multiple coagulation factor deficiency 2 (Mcfd2), 1810021C21Rik, DKFZp469B098, F5F8D, F5f8d, F5F8D2, hm:zeh1186, LMAN1IP, Lman1ip, MCFD2, SDNSF, Sdnsf, wu:fc23b10, wu:fd50d08, zgc:103713, zgc:109915Bezeichner auf Proteinebene für MCFD2
- multiple coagulation factor deficiency 2
- multiple coagulation factor deficiency protein 2
- Multiple coagulation factor deficiency protein 2 homolog
- neural stem cell derived neuronal survival protein
- neural stem cell-derived neuronal survival protein
- multiple coagulation factor deficiency protein 2 homolog
- stem cell derived neuronal survival protein
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