MED12 Produkte
(Mediator Complex Subunit 12 (MED12))
Kategorien
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
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Ausgewählte MED12 Kategorien
MED12 Antikörper
High quality antibodies with extensive validation data.
MED12 ELISA Kits
Reliable ELISA kits for a wide range of species.
Empfohlene MED12 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN6242936
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7159104
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7243679
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene MED12 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN1743269
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Sheep
Analytical Method
Validierungen
Kat. Nr.
ABIN1774174
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN1744488
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MED12 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310630
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MED12 Produkten
: "H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas." in: Oncogene, Vol. 38, Issue 27, pp. 5356-5366, (2019) (PubMed).: "Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6." in: Journal of medicinal chemistry, Vol. 59, Issue 19, pp. 9124-9139, (2016) (PubMed).
: "Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 15, pp. 6679-90, (2013) (PubMed).
: "Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription." in: PLoS ONE, Vol. 8, Issue 10, pp. e78242, (2013) (PubMed).
: "Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation." in: Biochimie, Vol. 94, Issue 8, pp. 1828-32, (2012) (PubMed).
: "Control of ground-state pluripotency by allelic regulation of Nanog." in: Nature, Vol. 483, Issue 7390, pp. 470-3, (2012) (PubMed).
: "MED12 alterations in both human benign and malignant uterine soft tissue tumors." in: PLoS ONE, Vol. 7, Issue 6, pp. e40015, (2012) (PubMed).
: "Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines." in: Experimental hematology, Vol. 40, Issue 10, pp. 800-10, (2012) (PubMed).
: "A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 2, pp. 348-59, (2011) (PubMed).
: "Core promoter recognition complex changes accompany liver development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 10, pp. 3906-11, (2011) (PubMed).
Synonyme und alternative Namen zu MED12
mediator complex subunit 12 (MED12), mediator complex subunit 12 (Med12), mediator complex subunit 12 (med12), 230kDa, ARC240, CAGH45, FGS1, HOPA, MED12S, Mopa, OHDOX, OKS, OPA-1, OPA1, TNRC11, Tnrc11, TRAP230, Trap230Bezeichner auf Proteinebene für MED12
- CAG repeat protein 45
- OPA-containing protein
- activator-recruited cofactor 240 kDa component
- human opposite paired
- mediator of RNA polymerase II transcription subunit 12
- mediator of RNA polymerase II transcription, subunit 12 homolog
- putative mediator subunit 12
- thyroid hormone receptor-associated protein complex 230 kDa component
- thyroid hormone receptor-associated protein, 230 kDa subunit
- trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
- trinucleotide repeat-containing gene 11 protein
- trinucleotide repeat containing 11
- OPA-containing protein 1
- mediator complex subunit 12
- trinucleotide repeat containing 11 (THR-associated protein)
- kohtalo
- kto
- mot_m807
- motionless
- protein kohtalo
- protein motionless
- shiri
- shr
- thyroid hormone receptor-associated protein 230
- thyroid hormone receptor-associated protein complex component TRAP230
- trap230
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