MEG3 Produkte
(Family with Sequence Similarity 129, Member B (FAM129B))
Kategorien
MEG3 (Maternally Expressed Gene 3) is a long non-coding RNA (lncRNA) that is part of the DLK1-MEG3 locus on chromosome 14q32.3. This locus is imprinted, meaning that genes from only one parental allele are expressed while the other allele is silenced. Specifically, MEG3 is maternally expressed and paternally silenced.
- Tumor Suppressor: MEG3 has been identified as a tumor suppressor in various types of cancers. Its expression is often downregulated in tumor tissues compared to normal tissues. The loss of MEG3 expression has been associated with tumor progression and poor prognosis in several cancers.
- Regulation of Cell Proliferation and Apoptosis: MEG3 plays a role in controlling cell proliferation and promoting apoptosis. Its downregulation can lead to increased cell proliferation and reduced apoptosis, which can contribute to tumorigenesis.
- Modulation of p53 Pathway: MEG3 can enhance the activity of the p53 protein, a critical tumor suppressor. By modulating the p53 pathway, MEG3 can influence cell cycle arrest, apoptosis, and DNA repair.
- Role in Neural Development: Apart from its role in cancer, MEG3 is also involved in neural development. It is expressed in the brain and has been implicated in the differentiation of neural stem cells.
- Interaction with Other Molecules: As an lncRNA, MEG3 can interact with various molecules in the cell, including proteins, other RNAs, and DNA. These interactions can influence gene expression, protein activity, and cellular functions.
- Epigenetic Regulation: MEG3 is involved in the epigenetic regulation of genes. It can recruit chromatin-modifying enzymes to specific genomic regions, leading to changes in gene expression.
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Ausgewählte MEG3 Kategorien
MEG3 Antikörper
High quality antibodies with extensive validation data.
MEG3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MEG3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (1)
Kat. Nr.
ABIN6254107
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IF, ELISA, ICC
Validierungen
- (1)
Kat. Nr.
ABIN7095788
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF
Validierungen
- (2)
Kat. Nr.
ABIN363056
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene MEG3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6230630
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MEG3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2727264
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MEG3 Produkten
: "Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163." in: Tumour biology, Vol. 37, Issue 3, pp. 3925-31, (2016) (PubMed).: "Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway." in: American journal of translational research, Vol. 8, Issue 2, pp. 1091-9, (2016) (PubMed).
: "FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells." in: F1000Research, Vol. 2, pp. 134, (2014) (PubMed).
Synonyme und alternative Namen zu MEG3
family with sequence similarity 129 member B (FAM129B), family with sequence similarity 129 member B S homeolog (fam129b.S), family with sequence similarity 129 member B (fam129b), family with sequence similarity 129, member B (Fam129b), family with sequence similarity 129, member Ba (fam129ba), 9130404D14Rik, bA356B19.6, C9orf88, fam129b, MEG-3, MGC82535, MINERVA, OC58, RGD1307018, zgc:158319Bezeichner auf Proteinebene für MEG3
- melanoma invasion by ERK
- niban-like protein 1
- family with sequence similarity 129, member B
- hypothetical protein LOC100145245
- Niban-like protein 1
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