Mitogen-Activated Protein Kinase Kinase 2 Produkte
(Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
Kategorien
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte Mitogen-Activated Protein Kinase Kinase 2 Kategorien
Mitogen-Activated Protein Kinase Kinase 2 Antikörper
High quality antibodies with extensive validation data.
Mitogen-Activated Protein Kinase Kinase 2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Mitogen-Activated Protein Kinase Kinase 2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Mitogen-Activated Protein Kinase Kinase 2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN726500
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7439504
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF, IHC (p)
Validierungen
- (5)
Kat. Nr.
ABIN392485
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene Mitogen-Activated Protein Kinase Kinase 2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380638
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730501
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Dog
Analytical Method
Validierungen
Kat. Nr.
ABIN1130729
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Mitogen-Activated Protein Kinase Kinase 2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Source
Insect cells (Sf9)
Validierungen
- (1)
Kat. Nr.
ABIN5624615
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123999
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310171
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Mitogen-Activated Protein Kinase Kinase 2 Produkten
: "Follicular fluid meiosis-activating sterol (FF-MAS) promotes meiotic resumption via the MAPK pathway in porcine oocytes." in: Theriogenology, (2019) (PubMed).: "The MEK/ERK cascade: from signaling specificity to diverse functions." in: Biochimica et biophysica acta, Vol. 1773, Issue 8, pp. 1213-26, (2007) (PubMed).
: "Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18574-9, (2006) (PubMed).
: "Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ..." in: Molecular cancer research : MCR, Vol. 1, Issue 4, pp. 312-22, (2003) (PubMed).
: "Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2." in: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7177-88, (2003) (PubMed).
: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).
: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, (2003) (PubMed).
Synonyme und alternative Namen zu Mitogen-Activated Protein Kinase Kinase 2
mitogen-activated protein kinase kinase 2 (MAP2K2), mitogen-activated protein kinase kinase 2 (Map2k2), mitogen activated protein kinase kinase 2 (Map2k2), MAP kinase kinase 2 (MKK2), mitogen-activated protein kinase kinase 2a (map2k2a), mitogen-activated protein kinase kinase 2b (map2k2b), AA589381, ATMKK2, CFC4, F27B13.50, F27B13_50, map2k2, MAP KINASE KINASE 1, MAP kinase kinase 2, MAPKK2, MEK2, MK1, MK2, MKK2, PRKMK2, Prkmk2, wu:fa56c06, zgc:123171, zgc:172250Bezeichner auf Proteinebene für Mitogen-Activated Protein Kinase Kinase 2
- ERK activator kinase 2
- MAP kinase kinase 2
- MAPK/ERK kinase 2
- dual specificity mitogen-activated protein kinase kinase 2
- mitogen-activated protein kinase kinase 2, p45
- MAP kinase/Erk kinase
- MAPKK 2
- MEK 2
- mitogen activated protein kinase kinase 2
- protein kinase, mitogen activated, kinase 2, p45
- MEK2
- mitogen-activated protein kinase kinase type 2
- dual specificity mitogen activated protein kinase kinase 2
- fa56c06
- mitogen-activated protein kinase kinase 2
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