MLL/KMT2A Produkte
(Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
Kategorien
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010].
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Ausgewählte MLL/KMT2A Kategorien
MLL/KMT2A Antikörper
High quality antibodies with extensive validation data.
MLL/KMT2A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MLL/KMT2A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
IHC, ELISA
Validierungen
- (4)
Kat. Nr.
ABIN7189494
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA
Validierungen
- (3)
- (2)
Kat. Nr.
ABIN969286
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA, FACS, ICC, Neut
Validierungen
- (3)
Kat. Nr.
ABIN7193384
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene MLL/KMT2A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN6579161
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MLL/KMT2A Produkten
: "The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism." in: Oncotarget, Vol. 7, Issue 23, pp. 35341-52, (2016) (PubMed).: "Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells." in: Oncotarget, Vol. 7, Issue 26, pp. 40594-40620, (2016) (PubMed).
: "Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer." in: Biochimica et biophysica acta, Vol. 1849, Issue 6, pp. 697-708, (2015) (PubMed).
: "Targeting the MLL complex in castration-resistant prostate cancer. ..." in: Nature medicine, Vol. 21, Issue 4, pp. 344-52, (2015) (PubMed).
: "NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1." in: Nature structural & molecular biology, Vol. 22, Issue 4, pp. 312-8, (2015) (PubMed).
: "Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL." in: Oncogenesis, Vol. 3, pp. e127, (2014) (PubMed).
: "Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins." in: Nucleic acids research, Vol. 42, Issue 14, pp. 9021-32, (2014) (PubMed).
: "RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction." in: Cell reports, Vol. 3, Issue 1, pp. 116-27, (2013) (PubMed).
: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, (2010) (PubMed).
: "Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 21, Issue 2, pp. 360-2, (2007) (PubMed).
Synonyme und alternative Namen zu MLL/KMT2A
lysine methyltransferase 2A (KMT2A), lysine (K)-specific methyltransferase 2A (Kmt2a), lysine methyltransferase 2A (Kmt2a), 6430520K01, ALL-1, All1, CXXC7, Cxxc7, HRX, HTRX1, mKIAA4050, MLL, Mll, MLL/GAS7, Mll1, MLL1A, TET1-MLL, TRX1, WDSTSBezeichner auf Proteinebene für MLL/KMT2A
- CDK6/MLL fusion protein
- CXXC-type zinc finger protein 7
- MLL-AF4 der(11) fusion protein
- MLL/GAS7 fusion protein
- MLL/GMPS fusion protein
- histone-lysine N-methyltransferase 2A
- lysine N-methyltransferase 2A
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
- myeloid/lymphoid or mixed-lineage leukemia protein 1
- trithorax-like protein
- zinc finger protein HRX
- histone-lysine N-methyltransferase MLL
- myeloid/lymphoid or mixed-lineage leukemia 1
- trithorax Drosophila
- Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
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