NAE1 Produkte
(NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
Kategorien
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte NAE1 Kategorien
NAE1 Antikörper
High quality antibodies with extensive validation data.
NAE1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NAE1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (4)
Kat. Nr.
ABIN563865
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN391418
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7161137
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene NAE1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1311928
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124126
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2130748
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NAE1 Produkten
: "PPARγ neddylation essential for adipogenesis is a potential target for treating obesity." in: Cell death and differentiation, Vol. 23, Issue 8, pp. 1296-311, (2016) (PubMed).: "More than the sum of its parts." in: Cell reports, Vol. 1, Issue 1, pp. 1, (2012) (PubMed).
: "A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924." in: Cell reports, Vol. 1, Issue 4, pp. 309-16, (2012) (PubMed).
: "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8." in: Nature, Vol. 422, Issue 6929, pp. 330-4, (2003) (PubMed).
: "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis." in: Journal of neurochemistry, Vol. 85, Issue 3, pp. 801-9, (2003) (PubMed).
: "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain." in: The Journal of cell biology, Vol. 163, Issue 1, pp. 27-33, (2003) (PubMed).
: "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8929-35, (2000) (PubMed).
: "Covalent modification of all members of human cullin family proteins by NEDD8." in: Oncogene, Vol. 18, Issue 48, pp. 6829-34, (2000) (PubMed).
: "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11339-46, (1996) (PubMed).
Synonyme und alternative Namen zu NAE1
beta-Amyloid precursor protein binding protein 1 (APP-BP1), NEDD8 activating enzyme E1 subunit 1 (NAE1), NEDD8 activating enzyme E1 subunit 1 (Nae1), NEDD8 activating enzyme E1 subunit 1 S homeolog (nae1.S), nedd8 activating enzyme E1 subunit 1 (nae1), NEDD8-activating enzyme E1 regulatory subunit (ula-1), 59kDa, A-116A10.1, anon-WO0140519.225, APPBP1, Appbp1, appbp1, CG7828, dAPP-BP1, dAPPBP1, Dmel\\CG7828, ula-1, zgc:66148Bezeichner auf Proteinebene für NAE1
- APP-BP1-PA
- APP-BP1-PB
- CG7828-PA
- CG7828-PB
- APP-BP1
- NEDD8-activating enzyme E1 regulatory subunit
- NEDD8-activating enzyme E1 subunit
- amyloid beta precursor protein binding protein 1, 59kDa
- amyloid beta precursor protein-binding protein 1, 59 kDa
- amyloid beta precursor protein-binding protein 1, 59kD
- amyloid protein-binding protein 1
- proto-oncogene protein 1
- protooncogene protein 1
- APP-binding protein 1
- amyloid beta precursor protein binding protein 1
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