Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Nemo-Like Kinase Produkte

(Nemo-Like Kinase (NLK))
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

antibodies-online.com steht für hochwertige Forschungsprodukte. Suchen, finden und bestellen Sie Tools mit umfangreichen Validierungsdaten, Bildern, Referenzen. Unser wissenschaftlicher Kundenservice steht Ihnen jederzeit zur Verfügung, wenn Sie Fragen zur Auswahl oder Anwendung unserer Produkte haben.

Ausgewählte Nemo-Like Kinase Kategorien

Nemo-Like Kinase Antikörper

High quality antibodies with extensive validation data.

Nemo-Like Kinase ELISA Kits

Reliable ELISA kits for a wide range of species.

Nemo-Like Kinase Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Nemo-Like Kinase Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, PLA
Validierungen
  • (7)
Kat. Nr. ABIN526866
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF, IHC (p), ICC
Validierungen
  • (4)
Kat. Nr. ABIN2856544
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF, FACS
Validierungen
  • (3)
Kat. Nr. ABIN652357
Menge 400 μL
Datenblatt Datenblatt

Empfohlene Nemo-Like Kinase ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6951471
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1157306
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN1157307
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Nemo-Like Kinase Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (2)
Kat. Nr. ABIN1312656
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1312658
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Baculovirus infected Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN7317069
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Nemo-Like Kinase Produkten

Boehm, Gewurz, Kieff, Cahir-McFarland: "Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 42, pp. 18103-8, (2010) (PubMed).

Ohkawara, Shirakabe, Hyodo-Miura, Matsuo, Ueno, Matsumoto, Shibuya: "Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction." in: Genes & development, Vol. 18, Issue 4, pp. 381-6, (2004) (PubMed).

Yasuda, Tsuchiya, Yamada, Sakamoto, Sekiya, Hirohashi: "Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells." in: Biochemical and biophysical research communications, Vol. 308, Issue 2, pp. 227-33, (2003) (PubMed).

Ishitani, Ninomiya-Tsuji, Matsumoto: "Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1379-89, (2003) (PubMed).

Ishitani, Kishida, Hyodo-Miura, Ueno, Yasuda, Waterman, Shibuya, Moon, Ninomiya-Tsuji, Matsumoto: "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 131-9, (2002) (PubMed).

Kehrer-Sawatzki, Moschgath, Maier, Legius, Elgar, Krone: "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts." in: Gene, Vol. 251, Issue 1, pp. 63-71, (2000) (PubMed).

Synonyme und alternative Namen zu Nemo-Like Kinase

glucose-6-phosphate isomerase (Gpi), nemo like kinase (NLK), nemo like kinase (Nlk), nemo-like kinase, type 1 (nlk1), nemo-like kinase L homeolog (nlk.L), nemo like kinase (nlk), Nemo-Like kinase (nemo-like), nemo-like kinase (nlk), AI194375, Amf, Gpi1, nemo-like, nlk, NLK, nlk1, nlk2, nlkb, RGD1561602, Xnlk, zgc:111875

Bezeichner auf Proteinebene für Nemo-Like Kinase

  • NLK
  • PGI
  • PHI
  • autocrine motility factor
  • glucose phosphate isomerase
  • neuroleukin
  • phosphoglucose isomerase
  • phosphohexose isomerase
  • serine/threonine-protein kinase NLK
  • nemo-like kinase
  • serine/threonine protein kinase NLK
  • nemo like kinase b
  • nemo-like kinase 2
  • Nemo-like kinase
  • Serine/threonine-protein kinase NLK
  • nemo like kinase
  • Nemo-Like kinase
  • serine/threonine-protein kinase NLK-like
Sie sind hier:
Kundenservice