Notch1 Produkte
(Notch 1 (NOTCH1))
Kategorien
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008].
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Ausgewählte Notch1 Kategorien
Notch1 Antikörper
High quality antibodies with extensive validation data.
Notch1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Notch1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Notch1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
FACS
Validierungen
- (6)
- (4)
Kat. Nr.
ABIN807924
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
FACS
Validierungen
- (6)
- (4)
Kat. Nr.
ABIN2749161
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN675114
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Notch1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958221
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958222
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958223
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Notch1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7275363
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7275364
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Human Cells
Validierungen
- (1)
Kat. Nr.
ABIN7320796
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Notch1 Produkten
: "Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway." in: Scientific reports, Vol. 10, Issue 1, pp. 5708, (2020) (PubMed).: "Altered expression of Notch1 in Alzheimer's disease." in: PLoS ONE, Vol. 14, Issue 11, pp. e0224941, (2020) (PubMed).
: "Enhanced lysosomal degradation maintains the quiescent state of neural stem cells." in: Nature communications, Vol. 10, Issue 1, pp. 5446, (2019) (PubMed).
: "Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling." in: Cell stem cell, Vol. 23, Issue 4, pp. 530-543.e9, (2018) (PubMed).
: "Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations." in: Scientific reports, Vol. 8, Issue 1, pp. 17987, (2018) (PubMed).
: "Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases." in: Clinical oral investigations, (2017) (PubMed).
: "NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis." in: Stem cells (Dayton, Ohio), Vol. 35, Issue 4, pp. 1106-1119, (2017) (PubMed).
: "Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning." in: Developmental cell, Vol. 40, Issue 5, pp. 505-511.e6, (2017) (PubMed).
: "Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1." in: The Journal of biological chemistry, Vol. 292, Issue 2, pp. 732-747, (2017) (PubMed).
: "Chlamydia and ocular adnexal lymphomas: An Indian experience." in: Experimental and molecular pathology, Vol. 101, Issue 1, pp. 74-80, (2016) (PubMed).
Synonyme und alternative Namen zu Notch1
notch 1 (notch1), fibropellin-1 (LOC100631526), Notch homolog 1, translocation-associated (Drosophila) (NOTCH1), notch 1 (NOTCH1), Notch homolog 1, translocation-associated (NOTCH1), notch 1 (Notch1), notch 1 S homeolog (notch1.S), 9930111A19Rik, hn1, hN1, lin-12, Mis6, N1, notch, NOTCH, notch-1, notch1, NOTCH1, notch1-a, tan1, TAN1, Tan1, xnotch, xnotch1, xotch, XotchBezeichner auf Proteinebene für Notch1
- notch 1
- Notch homolog 1, translocation-associated (Drosophila)
- Notch homolog 1, translocation-associated
- neurogenic locus notch homolog protein 1
- translocation-associated notch protein TAN-1
- Motch A
- Notch gene homolog 1
- mT14
- major type A protein
- p300
- transmembrane receptor Notch1
- Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
- neurogenic locus notch protein homolog
- NOTCH-1
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