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NOTCH4 Produkte

(Notch 4 (NOTCH4))
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008].

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Ausgewählte NOTCH4 Kategorien

NOTCH4 Antikörper

High quality antibodies with extensive validation data.

NOTCH4 ELISA Kits

Reliable ELISA kits for a wide range of species.

NOTCH4 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene NOTCH4 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, ICC, IHC (p), IHC (fro)
Validierungen
  • (6)
Kat. Nr. ABIN7442495
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Cow, Guinea Pig, Horse, Human, Pig, Rat
Applikation WB, IHC
Validierungen
  • (3)
  • (4)
Kat. Nr. ABIN2777550
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7254322
Menge 200 μL
Datenblatt Datenblatt

Empfohlene NOTCH4 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6968973
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6958227
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6231564
Menge 96 tests
Datenblatt Datenblatt

Empfohlene NOTCH4 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Source HEK-293 Cells
Validierungen
  • (2)
Kat. Nr. ABIN7275367
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7415095
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Rat
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7415395
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren NOTCH4 Produkten

Gelsomino, Panza, Giordano, Barone, Gu, Spina, Catalano, Fuqua, Andò: "Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines." in: Cancer letters, Vol. 428, pp. 12-20, (2018) (PubMed).

Bhat, Sun, Weger, Raouf: "Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells." in: Stem cells and development, Vol. 25, Issue 7, pp. 522-9, (2016) (PubMed).

Soylu, Acar, Ozbey, Unal, Koksal, Bassorgun, Ciftcioglu, Ustunel: "Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma." in: Pathology oncology research : POR, Vol. 22, Issue 1, pp. 87-94, (2015) (PubMed).

Sun, Klauzinska, Lake, Lee, Santopietro, Raafat, Salomon, Callahan, Artavanis-Tsakonas: "Trp53 regulates Notch 4 signaling through Mdm2." in: Journal of cell science, Vol. 124, Issue Pt 7, pp. 1067-76, (2011) (PubMed).

Sekine, Moriyama, Koyanagi, Koyama, Ogata, Okumura, Yagita: "Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands." in: International immunology, Vol. 21, Issue 3, pp. 295-301, (2009) (PubMed).

Tang, Urs, Liaw: "Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site." in: Circulation research, Vol. 102, Issue 6, pp. 661-8, (2008) (PubMed).

Murphy, Lam, Wu, Kim, Vartanian, Bollen, Carlson, Wang: "Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10901-6, (2008) (PubMed).

Moriyama, Sekine, Koyanagi, Koyama, Ogata, Chiba, Hirose, Okumura, Yagita: "Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice." in: International immunology, Vol. 20, Issue 6, pp. 763-73, (2008) (PubMed).

Bray: "Notch signalling: a simple pathway becomes complex." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 678-89, (2006) (PubMed).

Takahashi, Cui, Kojima, Han, Yu, Tanabe, Yara, Matsuura, Matsushima, Nakayama, Arinami, Shen, Faraone, Tsuang: "Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples." in: Biological psychiatry, Vol. 54, Issue 2, pp. 129-35, (2003) (PubMed).

Synonyme und alternative Namen zu NOTCH4

notch 4 (NOTCH4), notch 4 (Notch4), neurogenic locus notch homolog protein 4 (LOC100712850), Int-3, INT3, Int3, N4, NOTCH3, Notch4

Bezeichner auf Proteinebene für NOTCH4

  • Notch homolog 4
  • neurogenic locus notch homolog protein 4
  • notch 4
  • neurogenic locus notch homolog protein 4-like
  • Notch gene homolog 4
  • putative Notch4 protein
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