NPC1L1 Produkte
(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
Kategorien
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
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Ausgewählte NPC1L1 Kategorien
NPC1L1 Antikörper
High quality antibodies with extensive validation data.
NPC1L1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NPC1L1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (5)
- (1)
Kat. Nr.
ABIN1881583
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN1804672
Menge
50 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (1)
Kat. Nr.
ABIN7127645
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene NPC1L1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (2)
Kat. Nr.
ABIN7491703
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN7490787
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2854025
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NPC1L1 Produkten
: "Lipid-lowering effects of Coffea arabica pulp aqueous extract in Caco-2 cells and hypercholesterolemic rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 52, pp. 187-197, (2019) (PubMed).: "The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling." in: JCI insight, Vol. 4, Issue 3, (2019) (PubMed).
: "Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice." in: Molecular pharmacology, Vol. 96, Issue 1, pp. 47-55, (2019) (PubMed).
: "NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains." in: Journal of lipid research, Vol. 59, Issue 11, pp. 2181-2187, (2018) (PubMed).
: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).
: "Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane." in: Nutrition & metabolism, Vol. 13, pp. 48, (2016) (PubMed).
: "Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression." in: Molecular metabolism, Vol. 5, Issue 11, pp. 1092-1102, (2016) (PubMed).
: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." in: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).
: "Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters." in: Journal of agricultural and food chemistry, Vol. 65, Issue 2, pp. 276-280, (2016) (PubMed).
: "NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy." in: Science translational medicine, Vol. 7, Issue 275, pp. 275ra23, (2015) (PubMed).
Synonyme und alternative Namen zu NPC1L1
NPC1 like intracellular cholesterol transporter 1 (NPC1L1), NPC1 like 1 (npc1l1), NPC1-like 1 (npc1l1), NPC1 like intracellular cholesterol transporter 1 (Npc1l1), 9130221N23Rik, Gm243, NPC1L1, NPC11L1Bezeichner auf Proteinebene für NPC1L1
- NPC1-like 1
- NPC1 (Niemann-Pick disease, type C1, gene)-like 1
- Niemann-Pick C1-like protein 1
- Niemann-Pick C1-like 1 protein
- Niemann-Pick C1-like protein 1-like
- Niemann-Pick disease, type C1
- Niemann-Pick disease, type C1-like 1
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