NR1I2 Produkte
(Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
Kategorien
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008].
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Ausgewählte NR1I2 Kategorien
NR1I2 Antikörper
High quality antibodies with extensive validation data.
NR1I2 ELISA Kits
Reliable ELISA kits for a wide range of species.
NR1I2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NR1I2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
- (6)
Kat. Nr.
ABIN738816
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, FACS, IHC (p), IF
Validierungen
- (5)
Kat. Nr.
ABIN652618
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, FACS, ICC
Validierungen
- (5)
Kat. Nr.
ABIN5542364
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene NR1I2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6958259
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969013
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969012
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene NR1I2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1312940
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1787822
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7397780
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NR1I2 Produkten
: "Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis." in: Pediatric research, Vol. 83, Issue 5, pp. 1031-1040, (2018) (PubMed).: "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." in: Scientific reports, Vol. 6, pp. 27876, (2016) (PubMed).
: "Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell." in: The international journal of biochemistry & cell biology, Vol. 72, pp. 73-88, (2016) (PubMed).
: "Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays." in: Analytical biochemistry, Vol. 509, pp. 124-9, (2016) (PubMed).
: "St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins." in: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, Vol. 66, Issue 2, pp. 203-14, (2015) (PubMed).
: "Desmethyl bosentan displays a similar in vitro interaction profile as bosentan." in: Pulmonary pharmacology & therapeutics, Vol. 30, pp. 80-6, (2015) (PubMed).
: "3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease." in: Pharmacological research, Vol. 100, pp. 64-72, (2015) (PubMed).
: "Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines." in: The Journal of pharmacy and pharmacology, Vol. 67, Issue 11, pp. 1575-84, (2015) (PubMed).
: "Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats." in: Psychopharmacology, Vol. 231, Issue 17, pp. 3375-90, (2014) (PubMed).
: "Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro." in: Pulmonary pharmacology & therapeutics, Vol. 28, Issue 2, pp. 130-7, (2014) (PubMed).
Synonyme und alternative Namen zu NR1I2
nuclear receptor subfamily 1 group I member 2 (NR1I2), nuclear receptor subfamily 1, group I, member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 2 S homeolog (nr1i2.S), nuclear receptor subfamily 1, group I, member 2 (nr1i2), BXR, bxr, mPXR, nr1i2, ONR1, onr1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR, xonr1Bezeichner auf Proteinebene für NR1I2
- nuclear receptor subfamily 1 group I member 2
- orphan nuclear receptor PAR1
- orphan nuclear receptor PXR
- pregnane X nuclear receptor variant 2
- pregnane X receptor
- steroid and xenobiotic receptor
- Pregnane X receptor
- nuclear receptor subfamily 1, group 1, member 2
- pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
- nuclear receptor subfamily 1 group I member 2 S homeolog
- nuclear receptor subfamily 1, group I, member 2
- orphan nuclear receptor BXR-beta
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