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NUAK1 Produkte

(NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Kategorien

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.

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Ausgewählte NUAK1 Kategorien

NUAK1 Antikörper

High quality antibodies with extensive validation data.

NUAK1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene NUAK1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Hamster, Human, Mouse
Applikation WB, IHC (p)
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN392639
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, IHC (p)
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN392640
Menge 200 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
  • (2)
Kat. Nr. ABIN716396
Menge 100 μL
Datenblatt Datenblatt

Empfohlene NUAK1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6227500
Menge 96 tests
Datenblatt Datenblatt

Empfohlene NUAK1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1313130
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1313129
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
Kat. Nr. ABIN5509049
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren NUAK1 Produkten

Humbert, Navaratnam, Augert, Da Costa, Martien, Wang, Martinez, Abbadie, Carling, de Launoit, Gil, Bernard: "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." in: The EMBO journal, Vol. 29, Issue 2, pp. 376-86, (2010) (PubMed).

Niesler, Myburgh, Moore: "The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis." in: Experimental physiology, Vol. 92, Issue 1, pp. 207-17, (2007) (PubMed).

Suzuki, Lu, Kusakai, Kishimoto, Ogura, Esumi: "ARK5 is a tumor invasion-associated factor downstream of Akt signaling." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3526-35, (2004) (PubMed).

Kusakai, Suzuki, Ogura, Kaminishi, Esumi: "Strong association of ARK5 with tumor invasion and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 2, pp. 263-8, (2004) (PubMed).

Suzuki, Kusakai, Kishimoto, Lu, Ogura, Esumi: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation." in: Oncogene, Vol. 22, Issue 40, pp. 6177-82, (2003) (PubMed).

Suzuki, Kusakai, Kishimoto, Lu, Ogura, Lavin, Esumi: "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 48-53, (2002) (PubMed).

Synonyme und alternative Namen zu NUAK1

NUAK family kinase 1 (NUAK1), NUAK family, SNF1-like kinase, 1 (Nuak1), ARK5, AU014801, AW494241, B230104P22Rik, Omphk1

Bezeichner auf Proteinebene für NUAK1

  • AMP-activated protein kinase family member 5
  • AMPK-related protein kinase 5
  • NUAK family SNF1-like kinase 1
  • omphalocele kinase 1
  • ZNUAK family, SNF1-like kinase, 1
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