NUDT1 Produkte
(Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
Kategorien
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008].
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Ausgewählte NUDT1 Kategorien
NUDT1 Antikörper
High quality antibodies with extensive validation data.
NUDT1 ELISA Kits
Reliable ELISA kits for a wide range of species.
NUDT1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene NUDT1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
IHC, ELISA, IF
Validierungen
- (3)
Kat. Nr.
ABIN7142858
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP
Validierungen
- (3)
Kat. Nr.
ABIN518070
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN561864
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene NUDT1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969035
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730563
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6226065
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene NUDT1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1313165
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124237
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2130907
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren NUDT1 Produkten
: "The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress." in: Mutation research, Vol. 808, pp. 10-19, (2019) (PubMed).: "The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia." in: BMC cancer, Vol. 18, Issue 1, pp. 1190, (2019) (PubMed).
: "Potent and specific MTH1 inhibitors targeting gastric cancer." in: Cell death & disease, Vol. 10, Issue 6, pp. 434, (2019) (PubMed).
: "Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue." in: DNA repair, pp. 102644, (2019) (PubMed).
: "Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. ..." in: Nature communications, Vol. 9, Issue 1, pp. 250, (2018) (PubMed).
: "Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway." in: Journal of lipid research, Vol. 59, Issue 5, pp. 830-842, (2018) (PubMed).
: "Validating the concept of mutational signatures with isogenic cell models." in: Nature communications, Vol. 9, Issue 1, pp. 1744, (2018) (PubMed).
: "hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia." in: Oncogenesis, Vol. 5, Issue 12, pp. e275, (2016) (PubMed).
: "Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma." in: International journal of hematology, Vol. 105, Issue 3, pp. 318-325, (2016) (PubMed).
: "MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways." in: Oncogene, Vol. 34, Issue 20, pp. 2586-96, (2015) (PubMed).
Synonyme und alternative Namen zu NUDT1
7,8-dihydro-8-oxoguanine triphosphatase (mth1), 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498), nudix hydrolase 1 (nudt1), 7,8-dihydro-8-oxoguanine triphosphatase (8odp), nudix hydrolase 1 (NUDT1), nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1), nudix hydrolase 1 (Nudt1), MTH1, Mth1, mutT, nudT1Bezeichner auf Proteinebene für NUDT1
- 7,8-dihydro-8-oxoguanine triphosphatase
- 2-hydroxy-dATP diphosphatase
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
- 8-oxo-7,8-dihydroguanosine triphosphatase
- 8-oxo-dGTPase
- mutT human homolog 1
- nucleoside diphosphate-linked moiety X motif 1
- nucleoside diphosphate-linked moiety X-type motif 1
- nudix motif 1
- 8-oxo-7,8-dihydro-2'-dGTPase
- mutT human homolog (8-oxo-dGTPase)
- nudix-type motif 1
Haben Sie etwas anderes gesucht?
- NUDL
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 3
- NudE Neurodevelopment Protein 1
- NUDCD3
- NUDCD2
- NUDCD1
- NUDC
- Nucleotide Binding Protein 1
- Nucleostemin
- Nucleosome Assembly Protein 1-Like 4
- Nucleosome Assembly Protein 1-Like 1
- Nucleoside Monophosphate Kinase
- Nucleoside Diphosphate Kinase
- Nucleolin
- Nucleolar Protein 6
- Nucleolar Protein 1
- Nucleolar Complex Associated 4 Homolog
- Nucleolar and Spindle Associated Protein 1
- Nucleobindin 1
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