p130 Produkte
(Retinoblastoma-Like 2 (p130) (RBL2))
Kategorien
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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Ausgewählte p130 Kategorien
p130 Antikörper
High quality antibodies with extensive validation data.
p130 ELISA Kits
Reliable ELISA kits for a wide range of species.
p130 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene p130 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, FACS
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN656158
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, FACS
Validierungen
- (4)
Kat. Nr.
ABIN5542553
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Blow Fly, Chicken, Human, Mouse, Rat
Applikation
WB, IF, IHC, IP
Validierungen
- (5)
- (3)
Kat. Nr.
ABIN967864
Menge
150 μg
Datenblatt
Datenblatt
Empfohlene p130 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1155325
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1155326
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1155327
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene p130 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1317571
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2730602
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren p130 Produkten
: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).: "Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells." in: Molecular and cellular biology, Vol. 32, Issue 11, pp. 2065-82, (2012) (PubMed).
: "A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo." in: Oncogene, Vol. 26, Issue 13, pp. 1829-39, (2007) (PubMed).
: "From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway." in: Journal of cellular biochemistry, Vol. 102, Issue 6, pp. 1400-4, (2007) (PubMed).
: "Frequent loss of pRb2/p130 in human ovarian carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 9, pp. 3098-103, (2004) (PubMed).
: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, (2002) (PubMed).
: "The retinoblastoma family: twins or distant cousins?" in: Genome biology, Vol. 3, Issue 9, pp. reviews3012, (2002) (PubMed).
: "p107 and p130: versatile proteins with interesting pockets." in: Experimental cell research, Vol. 264, Issue 1, pp. 135-47, (2001) (PubMed).
Synonyme und alternative Namen zu p130
retinoblastoma-like 2 (p130) (RBL2), RB transcriptional corepressor like 2 (RBL2), related to retinoblastoma 2 (LOC541652), RB transcriptional corepressor like 2 (Rbl2), p130, P130, PRB2, Rb2, RBL2, RBR-2, RBR2, RRB2aBezeichner auf Proteinebene für p130
- retinoblastoma-like 2 (p130)
- retinoblastoma-like protein 2
- retinoblastoma-like protein 2-like
- CL1187_-3
- CL1187_-3(342)
- CL1187_-3_ov
- PZA00193
- RB
- RRB2b
- Retinoblastoma-related protein 2
- nPZA00193.2
- retinoblastoma-related protein 2a
- 130 kDa retinoblastoma-associated protein
- retinoblastoma-related protein 2
- P130
- PPAR-alpha-interacting complex protein 128
- PRB2
- PRIC128
- RBR-2
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