PDE4B Produkte
(phosphodiesterase 4B, cAMP-Specific (PDE4B))
Kategorien
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Ausgewählte PDE4B Kategorien
PDE4B Antikörper
High quality antibodies with extensive validation data.
PDE4B ELISA Kits
Reliable ELISA kits for a wide range of species.
PDE4B Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PDE4B Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC, IP, ICC
Validierungen
- (6)
Kat. Nr.
ABIN7442141
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN185574
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7146632
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PDE4B ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969261
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958532
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5657767
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PDE4B Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1314464
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7414258
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3094409
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PDE4B Produkten
: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." in: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).
: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).
: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).
: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).
: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).
Synonyme und alternative Namen zu PDE4B
phosphodiesterase 4B (pde4b), phosphodiesterase 4B (PDE4B), phosphodiesterase 4B, cAMP specific (Pde4b), phosphodiesterase 4B (Pde4b), phosphodiesterase 4B S homeolog (pde4b.S), dpde4, Dpde4, DPDE4, dunce, PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4, pde4b5, PDE4B5, pdeivb, PDEIVB, R74983Bezeichner auf Proteinebene für PDE4B
- phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog)
- phosphodiesterase 4B, cAMP-specific
- phosphodiesterase 4B
- 3',5'-cyclic AMP phosphodiesterase
- DPDE4
- Phosphodiesterase 4B cAMP-specific (dunce
- Phosphodiesterase 4B, cAMP-specific (dunce
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B
- PDE32
- cAMP-specific phosphodiesterase-4 B isoform
- dunce-like phosphodiesterase E4
- phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
- phosphodiesterase 4B, cAMP specific
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