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PDK3 Produkte

(Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Kategorien

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Ausgewählte PDK3 Kategorien

PDK3 Antikörper

High quality antibodies with extensive validation data.

PDK3 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PDK3 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA
Validierungen
  • (3)
  • (4)
Kat. Nr. ABIN562161
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB
Validierungen
  • (2)
  • (2)
Kat. Nr. ABIN391038
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, FACS
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN652286
Menge 400 μL
Datenblatt Datenblatt

Empfohlene PDK3 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6206626
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PDK3 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1314554
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1314553
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7417198
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PDK3 Produkten

Hou, Zhang, Han, Ge, Ma, Zhang, Moley, Schedl, Wang: "Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation." in: Journal of cell science, Vol. 128, Issue 13, pp. 2319-29, (2015) (PubMed).

Ho, Coomber: "Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells." in: Experimental cell research, Vol. 331, Issue 1, pp. 73-81, (2015) (PubMed).

Shimura, Nakai, Jiao, Osanai, Kashikura, Endo, Soga, Goda, Minamisawa: "Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 4, pp. H494-505, (2013) (PubMed).

Hwang, Wu, Harris: "Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet." in: The FEBS journal, Vol. 279, Issue 10, pp. 1883-93, (2012) (PubMed).

Halim, Mcfate, Mohyeldin, Okagaki, Korotchkina, Patel, Jeoung, Harris, Schell, Verma: "Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons." in: Glia, Vol. 58, Issue 10, pp. 1168-76, (2010) (PubMed).

Jeoung, Harris: "Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice." in: American journal of physiology. Endocrinology and metabolism, Vol. 295, Issue 1, pp. E46-54, (2008) (PubMed).

Lu, Lin, Chen, Lai, Tsai: "Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28106-14, (2008) (PubMed).

McFate, Mohyeldin, Lu, Thakar, Henriques, Halim, Wu, Schell, Tsang, Teahan, Zhou, Califano, Jeoung, Harris, Verma: "Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 33, pp. 22700-8, (2008) (PubMed).

Xu, Han, Epstein, Liu: "Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets." in: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 827-33, (2006) (PubMed).

Synonyme und alternative Namen zu PDK3

pyruvate dehydrogenase kinase 3 (PDK3), pyruvate dehydrogenase kinase 3 (Pdk3), pyruvate dehydrogenase kinase, isozyme 3a (pdk3a), pyruvate dehydrogenase kinase 3 (pdk3), pyruvate dehydrogenase kinase, isoenzyme 3 (Pdk3), fragile site, 5-azacytidine type, common, fra(1)(q12) (FRA1J), pyruvate dehydrogenase kinase, isozyme 3b (pdk3b), 2610001M10Rik, AI035637, pdk3, PDK3, zgc:158702

Bezeichner auf Proteinebene für PDK3

  • pyruvate dehydrogenase kinase, isoenzyme 3
  • pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
  • Pyruvate dehydrogenase kinase 3
  • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
  • pyruvate dehydrogenase kinase 3
  • pyruvate dehydrogenase kinase, isozyme 3
  • pyruvate dehydrogenase [lipoamide] kinase isozyme 3, mitochondrial-like
  • pyruvate dehydrogenase kinase, isozyme 3b
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