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PDP Produkte

(Pyruvate Dehydrogenase Phosphatase (PDP))
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].

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Ausgewählte PDP Kategorien

PDP Antikörper

High quality antibodies with extensive validation data.

PDP ELISA Kits

Reliable ELISA kits for a wide range of species.

PDP Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PDP Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Rat
Applikation WB, IHC (p)
Validierungen
  • (1)
  • (3)
Kat. Nr. ABIN656386
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (4)
Kat. Nr. ABIN6145404
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC
Validierungen
  • (3)
Kat. Nr. ABIN7262136
Menge 200 μL
Datenblatt Datenblatt

Empfohlene PDP ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6969803
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6959011
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN1116879
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PDP Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7392629
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7392626
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3011412
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PDP Produkten

Golias, Papandreou, Sun, Kumar, Brown, Swanson, Pai, Jaitin, Le, Teknos, Denko: "Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours." in: Scientific reports, Vol. 6, pp. 31146, (2016) (PubMed).

Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

Synonyme und alternative Namen zu PDP

Pyruvate dehydrogenase phosphatase (Pdp), pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial (LOC413080), pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog (pdp1.L), 153332_at, CG12151, Dmel\\CG12151, Gm1024, im:7157162, PDH, PDP, pdp, pdp1, PDPC, PPM2C, Ppm2c, ppm2c, zgc:174908

Bezeichner auf Proteinebene für PDP

  • CG12151-PA
  • CG12151-PB
  • Pdp-PA
  • Pdp-PB
  • pyruvate dehydrogenase phosphatase
  • PDP 1
  • PDPC 1
  • [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
  • protein phosphatase 2C, magnesium-dependent, catalytic subunit
  • pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
  • pyruvate dehydrogenase phosphatase catalytic subunit 1
  • protein phosphatase 2C, magnesium dependent, catalytic subunit
  • pyruvate dehydrogenase phosphatase isoenzyme 2
  • pyruvate dehydrogenase phosphatase isoenzyme 1
  • pyruvate dehydrogenase phosphatase, catalytic subunit 1
  • pyruvate dehyrogenase phosphatase catalytic subunit 1
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
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