PDP Produkte
(Pyruvate Dehydrogenase Phosphatase (PDP))
Kategorien
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].
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Ausgewählte PDP Kategorien
PDP Antikörper
High quality antibodies with extensive validation data.
PDP ELISA Kits
Reliable ELISA kits for a wide range of species.
PDP Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PDP Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IHC (p)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN656386
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (4)
Kat. Nr.
ABIN6145404
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC
Validierungen
- (3)
Kat. Nr.
ABIN7262136
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene PDP ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969803
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959011
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN1116879
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PDP Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7392629
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7392626
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN3011412
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PDP Produkten
: "Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours." in: Scientific reports, Vol. 6, pp. 31146, (2016) (PubMed).: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).
Synonyme und alternative Namen zu PDP
Pyruvate dehydrogenase phosphatase (Pdp), pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial (LOC413080), pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog (pdp1.L), 153332_at, CG12151, Dmel\\CG12151, Gm1024, im:7157162, PDH, PDP, pdp, pdp1, PDPC, PPM2C, Ppm2c, ppm2c, zgc:174908Bezeichner auf Proteinebene für PDP
- CG12151-PA
- CG12151-PB
- Pdp-PA
- Pdp-PB
- pyruvate dehydrogenase phosphatase
- PDP 1
- PDPC 1
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- protein phosphatase 2C, magnesium-dependent, catalytic subunit
- pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
- pyruvate dehydrogenase phosphatase catalytic subunit 1
- protein phosphatase 2C, magnesium dependent, catalytic subunit
- pyruvate dehydrogenase phosphatase isoenzyme 2
- pyruvate dehydrogenase phosphatase isoenzyme 1
- pyruvate dehydrogenase phosphatase, catalytic subunit 1
- pyruvate dehyrogenase phosphatase catalytic subunit 1
- pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
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