PEX5 Produkte
(Peroxisomal Biogenesis Factor 5 (PEX5))
Kategorien
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
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Ausgewählte PEX5 Kategorien
PEX5 Antikörper
High quality antibodies with extensive validation data.
PEX5 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PEX5 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN6145469
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC, IF
Validierungen
- (4)
Kat. Nr.
ABIN7261734
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Dog, Human, Monkey, Rat
Applikation
WB, IF, FACS
Validierungen
- (4)
Kat. Nr.
ABIN1500156
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PEX5 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6233831
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PEX5 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124372
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1314707
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3131369
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PEX5 Produkten
: "Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity." in: Journal of lipid research, Vol. 57, Issue 7, pp. 1133-43, (2016) (PubMed).: "A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS." in: Nature cell biology, Vol. 15, Issue 10, pp. 1186-96, (2013) (PubMed).
: "Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27243-51, (2009) (PubMed).
: "Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse)." in: The American journal of pathology, Vol. 159, Issue 4, pp. 1477-94, (2001) (PubMed).
: "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import." in: The Journal of cell biology, Vol. 147, Issue 4, pp. 761-74, (1999) (PubMed).
: "Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14." in: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5666-73, (1999) (PubMed).
: "A mouse model for Zellweger syndrome." in: Nature genetics, Vol. 17, Issue 1, pp. 49-57, (1997) (PubMed).
Synonyme und alternative Namen zu PEX5
peroxisomal biogenesis factor 5 (pex5), peroxisomal biogenesis factor 5 (Pex5), peroxisomal biogenesis factor 5 (PEX5), AW212715, ESTM1, PBD2A, PBD2B, Peroxin-5, PTS1-BP, PTS1R, Pxr1, PXR1, X83306Bezeichner auf Proteinebene für PEX5
- peroxisome biogenesis factor 5
- PTS1 receptor
- PTS1-BP
- PXR1P
- peroxin 5
- peroxisomal C-terminal targeting signal import receptor
- peroxisomal targeting signal 1 receptor
- peroxisome receptor 1
- peroxin-5
- peroxisomal targeting signal 1 (SKL type) receptor
- peroxisomal targeting signal import receptor
- peroxisomal targeting signal receptor 1
- PTS1R
- Peroxisomal C-terminal targeting signal import receptor
- Peroxisome receptor 1
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