Runt-Related Transcription Factor 1 (RUNX1) (N-Term) Peptid
RUNX1
Reaktivität: Human, Maus
Wirt: Synthetic
BP, WB
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- Target Alle RUNX1 Produkte
- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
- Protein Region
- N-Term
- Spezies
- Human, Maus
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- KMSEALPLGA PDGGPALASK LRSGDRSMVE VLADHPGELV RTDSPNFLCS
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Runx1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
- Synonyme
- RUNX1 Peptide, runx1 Peptide, AI462102 Peptide, AML1 Peptide, Cbfa2 Peptide, Pebp2a2 Peptide, Pebpa2b Peptide, AML1-EVI-1 Peptide, AMLCR1 Peptide, CBFA2 Peptide, EVI-1 Peptide, PEBP2aB Peptide, runxa Peptide, Runx-1 Peptide, XAML Peptide, Xaml1 Peptide, aml Peptide, aml-1 Peptide, aml1 Peptide, aml1-evi-1 Peptide, amlcr1 Peptide, cbfa2 Peptide, evi-1 Peptide, pebp2ab Peptide, Aml1 Peptide, uncharacterized LOC473981 Peptide, runt-related transcription factor Peptide, runt related transcription factor 1 Peptide, runt-related transcription factor 1 Peptide, runt related transcription factor 1 L homeolog Peptide, LOC473981 Peptide, runt Peptide, Runx1 Peptide, RUNX1 Peptide, runx1 Peptide, runx1.L Peptide
- Hintergrund
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CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation .
Alias Symbols: AI462102, AML1, Cbfa2, Pebp2a2, Pebpa2b
Protein Size: 387 - Molekulargewicht
- 42 kDa
- Gen-ID
- 12394
- NCBI Accession
- NM_009821, NP_033951
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