Reaktivität: Human
Wirt: Synthetic
Imm, BP
Dithiothreitol (DTT)
Beschränkungen
Nur für Forschungszwecke einsetzbar
Lagerung
-20 °C
Susa, Mortensen, Williams: "Effects of cations on protein and peptide charging in electrospray ionization from aqueous solutions." in: Journal of the American Society for Mass Spectrometry, Vol. 25, Issue 6, pp. 918-27, (2014) (PubMed).
Lindenburg, Tempels, Tjaden, van der Greef, Hankemeier: "On-line large-volume electroextraction coupled to liquid chromatography-mass spectrometry to improve detection of peptides." in: Journal of chromatography. A, Vol. 1249, pp. 17-24, (2012) (PubMed).
Lindenburg, Seitzinger, Tempels, Tjaden, van der Greef, Hankemeier: "Online capillary liquid-liquid electroextraction of peptides as fast pre-concentration prior to LC-MS." in: Electrophoresis, Vol. 31, Issue 23-24, pp. 3903-12, (2010) (PubMed).
Carr, Torres, Koch, Reiter: "Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs." in: Veterinary dermatology, Vol. 20, Issue 2, pp. 105-10, (2009) (PubMed).
Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist, a potent vasodilator and hypotensive agent, it induces salivation, it's a putative neurotransmitter in sensory (pain) afferents.