This is a synthetic peptide designed for use in combination with anti-SYNE3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
C14orf49
Reaktivität: Human, Maus
Wirt: Synthetic
BP
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
Nesprin3 (C14orf49)
(Chromosome 14 Open Reading Frame 49 (C14orf49))
Synonyme
C14orf49 Peptide, NET53 Peptide, Nesp3 Peptide, 4831426I19Rik Peptide, nesprin-3 Peptide, spectrin repeat containing nuclear envelope family member 3 Peptide, spectrin repeat containing, nuclear envelope family member 3 Peptide, SYNE3 Peptide, Syne3 Peptide
Hintergrund
SYNE3 is a component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. It is involved in the maintenance of nuclear organization and structural integrity. It is a probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. SYNE3 plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.