A synthetic peptide for use as a blocking control in assays to test for specificity of PSMB2 antibody, Alternative Names: PSMB2 control peptide, PSMB2 antibody Blocking Peptide, Anti-PSMB2 Blocking Peptide, Proteasome macropain subunit beta type 2 Blocking Peptide, Prosome Macropain Subunit Beta Type 2 Blocking Peptide, HC7-I Blocking Peptide, MGC104215 Blocking Peptide, MGC126885 Blocking Peptide, PSMB2, PSMB-2, PSMB 2, PSMB-2 Blocking Peptide, PSMB 2 Blocking Peptide
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB2 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.