A synthetic peptide for use as a blocking control in assays to test for specificity of MUC1 antibody, Alternative Names: MUC1 control peptide, MUC1 antibody Blocking Peptide, Anti-MUC1 Blocking Peptide, Mucin 1 Cell Surface Associated Blocking Peptide, CD227 Blocking Peptide, EMA Blocking Peptide, H23AG Blocking Peptide, MAM6 Blocking Peptide, PEM Blocking Peptide, PEMT Blocking Peptide, PUM Blocking Peptide, MUC1, MUC-1, MUC 1, MUC-1 Blocking Peptide, MUC 1 Blocking Peptide
Aufreinigung
Rabbit Anti-ATM (Phospho-Ser1981) Polyclonal Antibody is affinity purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide is removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 AA variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.