A synthetic peptide for use as a blocking control in assays to test for specificity of SF3 B3 antibody, Alternative Names: SF3B3 control peptide, SF3B3 antibody Blocking Peptide, Anti-SF3B3 Blocking Peptide, Splicing Factor 3B Subunit 3 130Kda Blocking Peptide, KIAA0017 Blocking Peptide, RSE1 Blocking Peptide, SAP130 Blocking Peptide, SF3b130 Blocking Peptide, STAF130 Blocking Peptide, SF3B3, SFB-3, SFB 3, SFB-3 Blocking Peptide, SFB 3 Blocking Peptide
SF3B3 is subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.