A synthetic peptide for use as a blocking control in assays to test for specificity of NSUN2 antibody, Alternative Names: NSUN2 control peptide, NSUN2 antibody Blocking Peptide, Anti-NSUN2 Blocking Peptide, Nol1/Nop2/Sun Domain Family Member 2 Blocking Peptide, FLJ20303 Blocking Peptide, MISU Blocking Peptide, SAKI Blocking Peptide, TRM4 Blocking Peptide, NSUN2, NSUN-2, NSUN 2, NSUN-2 Blocking Peptide, NSUN 2 Blocking Peptide
Optimal conditions should be determined by the investigator
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Handhabung
Avoid repeated freeze/thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20 °C long term.
Target
NSUN2
(NOP2/Sun Domain Family, Member 2 (NSUN2))
Synonyme
D13Wsu123e Peptide, Misu Peptide, MISU Peptide, MRT5 Peptide, SAKI Peptide, TRM4 Peptide, RGD1311954 Peptide, NOL1/NOP2/Sun domain family member 2 Peptide, NOP2/Sun RNA methyltransferase family member 2 Peptide, NOP2/Sun RNA methyltransferase family, member 2 Peptide, NOP2/Sun RNA methyltransferase family member 2 S homeolog Peptide, Nsun2 Peptide, NSUN2 Peptide, nsun2.S Peptide
Hintergrund
Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 is a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA).