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GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptid

GAPVD1 Reaktivität: Säugetier Wirt: Synthetic BP, IHC, WB
Produktnummer ABIN938336
  • Target Alle GAPVD1 Produkte
    GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
    Protein-Typ
    Synthetic
    Spezies
    Säugetier
    Quelle
    • 1
    Synthetic
    Applikation
    Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
    Sequenz
    FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ
    Produktmerkmale
    A synthetic peptide for use as a blocking control in assays to test for specificity of GAPVD1 antibody,
    Alternative Names: GAPVD1 control peptide, GAPVD1 antibody Blocking Peptide, Anti-GAPVD1 Blocking Peptide, Gtpase Activating Protein And Vps9 Domains 1 Blocking Peptide, DKFZP434C212 Blocking Peptide, KIAA1521 Blocking Peptide, MGC138847 Blocking Peptide, MGC138848 Blocking Peptide, RAP6 Blocking Peptide
  • Applikationshinweise
    Optimal conditions should be determined by the investigator
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
    Buffer
    PBS
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C long term.
  • Target
    GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
    Synonyme
    zgc:92666 Peptide, GAPEX5 Peptide, RAP6 Peptide, 2010005B09Rik Peptide, 4432404J10Rik Peptide, AW108497 Peptide, Gapex-5 Peptide, RME-6 Peptide, mKIAA1521 Peptide, RGD1307479 Peptide, GTPase activating protein and VPS9 domains 1 Peptide, GTPase activating protein and VPS9 domains 1 S homeolog Peptide, LOAG_00609 Peptide, GAPVD1 Peptide, gapvd1 Peptide, gapvd1.S Peptide, Gapvd1 Peptide
    Hintergrund
    GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
    Molekulargewicht
    166 kDa
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