A synthetic peptide for use as a blocking control in assays to test for specificity of HGF antibody, Alternative Names: HGF control peptide, HGF antibody Blocking Peptide, Anti-HGF Blocking Peptide, Hepatocyte Growth Factor Blocking Peptide, Hepapoietin A Scatter Factor Blocking Peptide, F-TCF Blocking Peptide, HGFB Blocking Peptide, HPTA Blocking Peptide, SF Blocking Peptide
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69 kDa alpha-chain and 34 kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity.